Decreased Hepatocyte Growth Factor (HGF) and Gamma Aminobutyric Acid (GABA) in Individuals with Obsessive-Compulsive Disorder (OCD).
Decreased Hepatocyte Growth Factor (HGF) and Gamma Aminobutyric Acid (GABA) in Individuals with Obsessive-Compulsive Disorder (OCD).
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DOI：
10.4137/bmi.s11931
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发表时间：
2013
影响因子：
3.8
通讯作者：
Pietsch SC
中科院分区：
文献类型：
--
作者：
Russo AJ;Pietsch SC
γ-氨基丁酸（GABA）在情绪障碍病因学中的作用得到了支持。最近的研究表明，肝细胞生长因子（HGF）调节GABA能抑制和癫痫易感性。本研究旨在测定强迫症（OCD）患者血浆HGF和GABA水平及其与症状严重程度的相关性。采用酶联免疫吸附试验（ELISA）对15名强迫症患者（9名男性，6名女性;平均年龄38.7岁）和17名神经正常对照（10名男性，7名女性;平均年龄35.2岁）的血浆中HGF、GABA、尿激酶纤溶酶原激活物（uPA）和尿激酶纤溶酶原激活物受体（uPAR）浓度进行了评估。这些强迫症患者的症状严重程度进行了评估，并与HGF和GABA浓度进行了比较。在这项初步研究中，强迫症患者的HGF水平显著降低，GABA和uPA的血浆水平降低。我们发现uPA和uPAR水平与HGF相关。在强迫症患者中，低uPA和低uPAR水平与高症状严重程度相关。强迫症患者的低GABA水平也与高症状严重程度相关。这些结果表明，HGF，GABA，uPA水平，和强迫症之间的初步关联，并建议，血浆GABA和uPA水平与强迫症患者的症状严重程度。
There is support for the role of gamma aminobutyric acid (GABA) in the etiology of mood disorders. Recent research has shown that hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility. This study was designed to determine and correlate plasma levels of HGF and GABA as well as symptom severity in individuals with obsessive-compulsive disorder (OCD). Plasma from 15 individuals with OCD (9 males, 6 females;, mean age 38.7 years) and 17 neurotypical controls (10 males, 7 females; mean age 35.2 years) was assessed for HGF, GABA, urokinase plasminogen activator (uPA), and urokinase plasminogen activator receptor (uPAR) concentration using enzyme-linked immunosorbest assays ELISAs. Symptom severity was assessed in these OCD individuals and compared with HGF and GABA concentrations. In this preliminary study, individuals with OCD had significantly decreased HGF levels, decreased plasma levels of GABA and decreased uPA. We found that both uPA and uPAR levels correlate with HGF. Both low uPA and low uPAR levels correlate with high symptom severity in individuals with OCD. Low GABA levels in OCD individuals also correlate with high symptom severity. These results demonstrate a preliminary association between HGF, GABA, uPA levels, and OCD and suggest that plasma GABA and uPA levels are related to symptom severity in individuals with OCD.