Plasma nitrogen oxides and blood lactate concentrations in Ghanaian children with malaria
Plasma nitrogen oxides and blood lactate concentrations in Ghanaian children with malaria
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DOI：
10.1016/s0035-9203(97)90083-3
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发表时间：
1997-05-01
影响因子：
2.2
通讯作者：
Krishna, S
中科院分区：
文献类型：
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作者：
Agbenyega, T;Angus, B;Krishna, S
一氧化氮是一种重要的宿主防御分子，也是许多病理生理过程中的介质。为了研究其在严重疟疾中的作用，我们测量了70名疟疾儿童（54名严重疟疾儿童）和48名对照组（33名医疗条件和15名手术患者）的血浆硝酸盐和亚硝酸盐浓度。我们将这些测量结果与血浆乳酸浓度相关联，血浆乳酸浓度是疟疾疾病严重程度的一个既定标志。在深度昏迷（P=0.0007）和有致死性结局的患者中，血浆乳酸水平显著升高，但平均一氧化氮浓度在两种结局类别中无显著差异，且与昏迷深度无关（P>0.5）。在检查脑脊液（CSF）的患者中，与存活者（3.4 mmol/L，n=13; P=0.032）相比，致死性病例（几何平均值8.2 mmol/L，n=5）的乳酸浓度升高;致死性病例的相应CSF一氧化氮浓度为10.7 μ M，而存活者为12.5 μ M（P=0.5）。血浆一氧化氮浓度与入院时寄生虫血症呈负相关（r=-0.41，n =70; P
Nitric oxide is an important host defence molecule as well as being a mediator in many: pathophysiological processes, To investigate its role in severe malaria, we measured plasma nitrate and nitrite concentrations in 70 children with malaria (54 with severe malaria) and 48 control subjects (33 with medical conditions and 15 surgical patients). We related these measurements to plasma lactate concentrations, an established marker of disease severity in malaria. Plasma lactate levels were significantly elevated in patients with deep coma (P=0.0007) and those with a fatal outcome,but mean nitrogen oxide concentrations were not significantly different in the 2 outcome categories and were not related to depth of coma (P>0.5). In patients whose cerebrospinal fluid (CSF) was examined, lactate concentrations were elevated in fatal cases (geometric mean 8.2 mmol/L, n=5) compared with survivors (3.4 mmol/L, n=13; P=0.032); corresponding CSF nitrogen oxide concentrations were 10.7 mu M in fatal cases compared with 12.5 mu M in survivors (P=0.5). Plasma nitrogen oxide concentrations were negatively correlated with admission parasitaemia (r=-0.41, n=70; P