Earth BioGenome Project: Sequencing life for the future of life
Earth BioGenome Project: Sequencing life for the future of life
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DOI：
10.1073/pnas.1720115115
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发表时间：
2018-04-24
影响因子：
11.1
通讯作者：
Zhang, Guojie
中科院分区：
文献类型：
--
作者：
Lewin, Harris A.;Robinson, Gene E.;Zhang, Guojie
增加我们对地球生物多样性的了解和负责任地管理其资源是新千年最重要的科学和社会挑战之一。这些挑战需要对地球上数百万生物体的组织、进化、功能和相互作用的基本新知识。在此，我们提出了地球生物基因组计划（EBP）的观点，这是一个旨在对地球上所有真核生物多样性的基因组进行测序，编目和表征的生物学登月计划。EBP的成果将为人类面临的一系列重大问题提供信息，例如气候变化对生物多样性的影响，濒危物种和生态系统的保护，以及生态系统服务的保护和增强。我们描述了该项目所面临的障碍，包括数据共享政策，以确保一个永久的，免费提供的资源，为未来的科学发现，同时尊重访问和惠益分享的名古屋议定书的指导方针。我们还描述了在执行这样一个雄心勃勃的项目的科学和组织的挑战，并提出了实现该项目的目标的结构。只有通过协调一致的国际努力，才能实现建立一个地球生命基因组信息开放数字库的深远潜在惠益。
Increasing our understanding of Earth's biodiversity and responsibly stewarding its resources are among the most crucial scientific and social challenges of the new millennium. These challenges require fundamental new knowledge of the organization, evolution, functions, and interactions among millions of the planet's organisms. Herein, we present a perspective on the Earth BioGenome Project (EBP), a moonshot for biology that aims to sequence, catalog, and characterize the genomes of all of Earth's eukaryotic biodiversity over a period of 10 years. The outcomes of the EBP will inform a broad range of major issues facing humanity, such as the impact of climate change on biodiversity, the conservation of endangered species and ecosystems, and the preservation and enhancement of ecosystem services. We describe hurdles that the project faces, including data-sharing policies that ensure a permanent, freely available resource for future scientific discovery while respecting access and benefit sharing guidelines of the Nagoya Protocol. We also describe scientific and organizational challenges in executing such an ambitious project, and the structure proposed to achieve the project's goals. The far-reaching potential benefits of creating an open digital repository of genomic information for life on Earth can be realized only by a coordinated international effort.