Associations Between Change in Sleep Duration and Inflammation: Findings on C-reactive Protein and Interleukin 6 in the Whitehall II Study
Associations Between Change in Sleep Duration and Inflammation: Findings on C-reactive Protein and Interleukin 6 in the Whitehall II Study
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DOI：
10.1093/aje/kwt072
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发表时间：
2013-09-15
影响因子：
5
通讯作者：
Shipley, Martin J.
中科院分区：
文献类型：
--
作者：
Ferrie, Jane E.;Kivimaeki, Mika;Shipley, Martin J.
横断面证据表明，睡眠时间与炎症标志物、C反应蛋白和白细胞介素-6水平之间存在关联。这项纵向研究使用了伦敦白厅II研究的数据，以研究睡眠时间的变化是否与间隔5年的2次测量的平均炎症水平相关。在1991/1994年和1997/1999年，对5,003名中年女性和男性的睡眠时间（平均每周晚上≥ 9小时）进行了评估。在1997/1999年和2002/2004年测量了C-反应蛋白和白细胞介素-6的空腹水平。横断面分析表明，较短的睡眠与较高水平的炎症标志物有关。纵向分析显示，1991/1994年至1997/1999年期间每晚睡眠时间每减少一小时，与1997/1999年和2002/2004年测量的平均C反应蛋白（8.1%）和白细胞介素-6（4.5%）水平较高相关。调整长期疾病和主要的心脏代谢危险因素表明，疾病过程可能是这些协会的部分基础。睡眠时间的增加与炎症标志物的平均水平无关。这些结果表明，睡眠时间短和睡眠减少都与5年内的平均炎症水平有关。
Cross-sectional evidence suggests associations between sleep duration and levels of the inflammatory markers, C-reactive protein and interleukin-6. This longitudinal study uses data from the London-based Whitehall II study to examine whether changes in sleep duration are associated with average levels of inflammation from 2 measures 5 years apart. Sleep duration (= 9 hours on an average week night) was assessed in 5,003 middle-aged women and men in 1991/1994 and 1997/1999. Fasting levels of C-reactive protein and interleukin-6 were measured in 1997/1999 and 2002/2004. Cross-sectional analyses indicated that shorter sleep is associated with higher levels of inflammatory markers. Longitudinal analyses showed that each hour per night decrease in sleep duration between 1991/1994 and 1997/1999 was associated with higher levels of C-reactive protein (8.1%) and interleukin-6 (4.5%) averaged across measures in 1997/1999 and 2002/2004. Adjustment for longstanding illness and major cardiometabolic risk factors indicated that disease processes may partially underlie these associations. An increase in sleep duration was not associated with average levels of inflammatory markers. These results suggest that both short sleep and reductions in sleep are associated with average levels of inflammation over a 5-year period.