Expression of somatostatin receptors in arginine vasopressin hormone-secreting olfactory neuroblastoma--report of two cases.
Expression of somatostatin receptors in arginine vasopressin hormone-secreting olfactory neuroblastoma--report of two cases.
复制标题
分泌精氨酸加压素激素的嗅神经母细胞瘤中生长抑素受体的表达——附二例报告。
作者：
S. Freeman;S. Mitra;T. H. Malik;P. Flanagan;P. Selby
客观化
精氨酸加压素激素分泌的嗅神经母细胞瘤极为罕见，文献中报道的病例不到20例。其中两个病例，都是以不适当的抗利尿激素综合征为首发症状。第二个肿瘤是用生长抑素受体(奥曲肽)放射闪烁照相术成功识别的。
方法
对两例患者的病理标本进行生长抑素受体免疫组织化学检测。
结果
这两个病例的样本都显示生长抑素受体呈阳性。
结论
这份报告展示了生长抑素类似物在嗅神经母细胞瘤患者的调查、随访和治疗中的潜在用途。
OBJECTIVE
Arginine vasopressin hormone-secreting olfactory neuroblastomas are extremely rare, with fewer than twenty cases reported in the literature. Two of these cases, both initially presenting with the syndrome of inappropriate antidiuretic hormone, are presented. The second tumour was successfully identified using somatostatin receptor (octreotide) radiographic scintography.
METHOD
The pathological specimens from both cases were examined immunohistochemically for somatostatin receptors.
RESULTS
Samples from both cases demonstrated positivity for somatostatin receptors.
CONCLUSIONS
This report demonstrates the potential use of somatastatin analogues in the investigation, follow-up and treatment of patients with olfactory neuroblastoma.