Efficacy of light versus tryptophan therapy in seasonal affective disorder
Efficacy of light versus tryptophan therapy in seasonal affective disorder
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DOI：
10.1016/s0165-0327(98)00053-6
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发表时间：
1998-07-01
影响因子：
6.6
通讯作者：
Gendron, MJ
中科院分区：
文献类型：
--
作者：
Ghadirian, AM;Murphy, BEP;Gendron, MJ
背景资料：虽然光疗法已成为季节性情感障碍（SAD，冬季抑郁症）患者的公认治疗方法，但几乎40%的患者没有反应，需要替代治疗。方法：采用重复测量设计，在13例SAD患者（11例女性，2例男性）中研究了光与色氨酸对SAD的治疗效果。给予光治疗2周或色氨酸治疗4周，间隔一周的洗脱期。在每次治疗开始和结束时采用改良汉密尔顿抑郁量表（SIGH-SAD）对所有患者进行评估。结果：4例（31%）患者对两种治疗均无反应。四名抗色氨酸患者对光疗法有反应，而一名抗光疗法的患者对色氨酸有反应。停止光治疗后复发迅速，但停止色氨酸治疗后没有复发。结论：光（p = 0.012）和色氨酸（p = 0.014）对SAD都有显著的治疗效果，它们彼此没有显著差异。停止治疗后残留药代动力学效应之间可能存在时间差。局限性：研究的群体较小。这是一项开放研究。临床相关性：色氨酸在治疗SAD方面与光疗法同样有效，但色氨酸停药后复发可能发生得更慢。(C)1998年Elsevier Science B.V.
Background: Although light therapy has become the accepted treatment for patients suffering from seasonal affective disorder (SAD, winter depression), almost 40% of these patients do not respond, and require an alternative treatment. Methods: The therapeutic effects of light versus tryptophan on SAD were studied in a repeated measures design in 13 SAD patients (11 women, 2 men). Light therapy for 2 weeks or tryptophan for 4 weeks was given, separated by a one week washout period. All were assessed with the modified Hamilton Depression Rating scale (SIGH-SAD) at the beginning and end of each treatment. Results: Four (31%) of the patients did not respond to either therapy. Four tryptophan-resistant patients responded to light therapy, while one Light therapy-resistant patient responded to tryptophan. Relapse occurred rapidly after stopping light therapy but not after stopping tryptophan therapy. Conclusions: There were significant therapeutic effects of both light (p = 0.012) and tryptophan (p = 0.014) on SAD, which were not significantly different from each other. There may be a time difference between the residual pharmacokinetic effects after stopping therapy. Limitations: The groups studied were small. This was an open study. Clinical Relevance: Tryptophan was equally effective to light therapy in treating SAD, but relapse after withdrawal of tryptophan probably occurs more slowly. (C) 1998 Elsevier Science B.V.