Hippocampal lesions and temporally chained conditioned stimuli in a conditioned suppression paradigm
Hippocampal lesions and temporally chained conditioned stimuli in a conditioned suppression paradigm
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条件抑制范式中的海马病变和时间链条件刺激
DOI：
10.3758/bf03327219
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
G. Borszcz
中科院分区：
文献类型：
--
作者：
R. N. Leaton;G. Borszcz
在barpress条件抑制范式下，将主要局限于海马背侧病变的大鼠与假手术对照组进行比较。在杠铃基线上的训练包括时间链不同的条件刺激（CSs），每30秒持续时间，从CS1开始，然后是一个冲击非条件刺激（US）。当CS1-US达到抑制标准时，动物进入CS2-CS1-US。训练就这样进行到CS4-CS3-CS2-CS1-US。海马损伤的大鼠学习CS1-US的速度与对照组一样快，但随着训练进展到其他CSs，它们相对于对照组逐渐失败。这个问题被解释为复杂迷宫学习中空间序列的时间模拟，而损伤引起的缺陷被解释为无法发展条件预期。我们主张根据条件反射的既定现象对海马体缺陷进行分析。
Rats with lesions restricted primarily to the dorsal hippocampus were compared with shamoperated controls in a barpress conditioned suppression paradigm. Training on the barpress baseline involved temporally chaining different conditioned stimuli (CSs), each 30 sec in duration, and began with CS1, followed by a shock unconditioned stimulus (US). When criteria for suppression were reached on CS1-US, the animal was advanced to CS2-CS1-US. Training progressed in this way to CS4-CS3-CS2-CS1-US. The rats with hippocampal lesions learned CS1-US as rapidly as controls did, but they progressively failed relative to the controls as training progressed to the other CSs. This problem is interpreted as a temporal analogue of the spatial sequence in complex maze learning, and the lesion-induced deficit is interpreted as an inability to develop conditioned expectancies. We argue for an analysis of hippocampal deficits in terms of the established phenomena of conditioning.