Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses.
Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses.
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DOI：
10.1038/srep25051
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发表时间：
2016-04-25
影响因子：
4.6
通讯作者：
Haynes L
中科院分区：
文献类型：
--
作者：
Lefebvre JS;Masters AR;Hopkins JW;Haynes L
滤泡辅助 T (TFH) 细胞反应对于流感感染期间产生保护性体液免疫至关重要。衰老对 CD4+ T 细胞功能和体液免疫产生深远影响，但衰老对抗原特异性 TFH 反应的影响仍不清楚。年轻和老年动物在感染过程中产生的流感特异性 TFH 细胞数量相似，但老年小鼠的 TFH 细胞表现出显着差异，包括 ICOS 表达减少以及 IL-10 和 IFNγ 产生增加，这可能会损害与同源 B 细胞的相互作用。此外，老年小鼠中更多的流感特异性 T 细胞具有调节表型，这可能导致 TFH 功能受损。对年轻 T 细胞的过继转移研究表明，衰老环境中的 TGF-β1 可以促进调节性 T 细胞积累增加。因此，衰老和衰老环境会影响抗原特异性 TFH 细胞的功能和形成，从而导致保护性体液反应减少。
T follicular helper (TFH) cell responses are essential for generation of protective humoral immunity during influenza infection. Aging has a profound impact on CD4+ T cell function and humoral immunity, yet the impact of aging on antigen specific TFH responses remains unclear. Influenza specific TFH cells are generated in similar numbers in young and aged animals during infection, but TFH cells from aged mice exhibit significant differences, including reduced expression of ICOS and elevated production of IL-10 and IFNγ, which potentially impairs interaction with cognate B cells. Also, more influenza specific T cells in aged mice have a regulatory phenotype, which could contribute to the impaired TFH function. Adoptive transfer studies with young T cells demonstrated that TGF-β1 in the aged environment can drive increased regulatory T cell accumulation. Aging and the aged environment thus impact antigen specific TFH cell function and formation, which contribute to reduced protective humoral responses.