MAMMOGRAPHIC FEATURES OF THE BREAST AND BREAST-CANCER RISK
MAMMOGRAPHIC FEATURES OF THE BREAST AND BREAST-CANCER RISK
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DOI：
10.1093/oxfordjournals.aje.a113320
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发表时间：
1982-01-01
影响因子：
5
通讯作者：
COLE, P
中科院分区：
文献类型：
--
作者：
BRISSON, J;MERLETTI, F;COLE, P
在美国马萨诸塞州波士顿的2家地区医院进行了一项病例对照研究，以评价干乳X线照片上可见的乳房解剖特征与乳腺癌风险的关系。病例为408例新诊断的乳腺癌妇女，对照组为1021例无乳腺疾病体征或症状的妇女。评估的乳房特征是Wolfe定义的实质模式和实质模式分类的组成部分的特定放射学特征。与N1型的女性相比，乳房X线照片显示P2或DY实质型的女性风险较高。此外，风险随着显示结节密度的乳房百分比的增加和显示结节密度的乳房百分比的增加以及这些密度的平均大小和浓度的增加而定期增加。具有广泛均匀密度的妇女也处于高风险中。这些发现仅在20-59岁的女性中观察到。在该组中，与乳房中没有结节密度的女性相比，乳房中60%或更多的结节密度的女性似乎具有5倍的风险增加。
A case-control study was conducted at 2 Boston, Massachusetts, USA, area hospitals to evaluate the relation of anatomic features of the breast, visible on the xeromammogram, to the risk of breast cancer. The cases were 408 women with newly diagnosed breast cancer and the controls were 1021 women without signs or symptoms of breast disease. The features of the breast assessed were the parenchymal pattern as defined by Wolfe, and specific radiologic characteristics which are components of the parenchymal pattern classification. Women whose mammogram showed the P2 or DY parenchymal patterns were at elevated risk compared to women with the N1 pattern. Further, risk increased regularly with increases in the percentage of the breast that showed nodular densities and with increases in the percentage of the breast that showed nodular densities and with increases in the average size and concentration of these densities. Women with extensive homogeneous density were also at elevated risk. These findings were observed only among women aged 20-59 yr. In this group, women with nodular densities in 60% or more of the breast appeared to have a 5-fold increase in risk compared to women without nodular densities in the breast.