The pace and shape of ageing
The pace and shape of ageing
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DOI：
10.1111/j.2041-210x.2010.00087.x
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发表时间：
2011-08-01
影响因子：
6.6
通讯作者：
Baudisch, Annette
中科院分区：
文献类型：
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作者：
Baudisch, Annette
1.人类会变老，但与其他物种相比，我们的年龄会增加或减少多少？人类比黑猩猩老得多，鸟类比鱼老得多，绵羊比水牛老得多吗？在这篇文章中，我认为，目前比较不同物种衰老模式的方法是有限的，因为它们混淆了年龄特异性变化的两个方面-衰老的速度和形状。基于速度和形状这两个轴，我引入了一个新的概念框架来分类物种的年龄。用这种方法，我根据物种的年龄（形状）和年龄（步伐）的强度对它们进行排名。根据它们是按速度还是按形状排列，物种的顺序不同。替代的步伐措施是高度相关的。替代形状测量也高度相关。速度和形状排名之间的相关性是负的，但很弱。在这里的例子中，没有一个物种是长寿的，但却表现出可忽略的衰老-与普遍持有的观点相反，长寿的物种是可忽略的衰老的良好候选者。分析物种的步伐形状空间提供了一个工具，以确定关键的决定因素的进化老化的物种在整个生命之树。
1. Humans age, but how much more or less do we age compared with other species? Do humans age more than chimps, birds more than fish or sheep more than buffalos? In this article, I argue that current methods to compare patterns of ageing across species are limited because they confound two dimensions of age-specific change - the pace and the shape of ageing.2. Based on the two axes of pace and shape, I introduce a new conceptual framework to classify how species age.3. With this method, I rank species according to how strongly they age (shape) and how fast they age (pace). Depending on whether they are ranked by pace or by shape, species are ordered differently.4. Alternative pace measures turn out to be highly correlated. Alternative shape measures are also highly correlated. The correlation between pace and shape ranking is negative but weak. Among the examples here, no species is long lived yet exhibits negligible ageing - contrary to the commonly held view that long-lived species are good candidates for negligible ageing.5. Analysis of species in pace-shape space provides a tool to identify key determinants of the evolution of ageing for species across the tree of life.