Could human papillomaviruses be spread through blood?
Could human papillomaviruses be spread through blood?
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DOI：
10.1128/jcm.43.11.5428-5434.2005
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发表时间：
2005-11-01
影响因子：
9.4
通讯作者：
Zheng, ZM
中科院分区：
文献类型：
--
作者：
Bodaghi, S;Wood, LV;Zheng, ZM
人乳头瘤病毒（hpv）是嗜上皮病毒，其生命周期需要分化的鳞状上皮环境。通过皮肤磨损或性交感染HPV会导致良性疣，有时还会导致癌症。在血液中检测到的HPV DNA被解释为起源于转移的癌细胞。本研究检测了1987年至1996年间收集的57名美国人类免疫缺陷病毒（HIV）感染的儿童患者的外周血单个核细胞（PBMCs）和2002年至2003年收集的19名健康献血者的新鲜外周血单个核细胞（PBMCs）中的HPV DNA。8名患者和3名献血者在HPV 16型基因组的两个亚组中大部分呈阳性。在所有11个PBMC样本中检测到的HPV基因组以episomal形式存在，尽管DNA拷贝数较低。8例患者中，7例通过输血感染（3例与血友病相关），1例通过垂直传播感染；该患者在采样前也接受了输血。我们的数据表明pbmc可能是HPV携带者，并可能通过血液传播病毒。
The human papillomaviruses (HPVs) are epitheliotropic viruses that require the environment of a differentiating squamous epithelium for their life cycle. HPV infection through abrasion of the skin or sexual intercourse causes benign warts and sometimes cancer. HPV DNA detected in the blood has been interpreted as having originated from metastasized cancer cells. The present study examined HPV DNA in banked, frozen peripheral blood mononuclear cells (PBMCs) from 57 U.S. human immunodeficiency virus (HIV)-infected pediatric patients collected between 1987 and 1996 and in fresh PBMCs from 19 healthy blood donors collected in 2002 to 2003. Eight patients and three blood donors were positive mostly for two subgroups of the HPV type 16 genome. The HPV genome detected in all 11 PBMC samples existed as an episomal form, albeit at a low DNA copy number. Among the eight patients, seven acquired HIV from transfusion (three associated with hemophilia) and one acquired HIV through vertical transmission; this patient also had received a transfusion before sampling. Our data suggest that PBMCs may be HPV carriers and might spread the virus through blood.