Surface studies of in vitro biocompatibility of titanium oxide coatings
Surface studies of in vitro biocompatibility of titanium oxide coatings
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DOI：
10.1016/s0169-4332(00)00844-8
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发表时间：
2001-03-01
影响因子：
6.7
通讯作者：
Scavia, G
中科院分区：
文献类型：
--
作者：
Casaletto, MP;Ingo, GM;Scavia, G
氧化钛涂层通常用于整形外科和牙科假体。尽管如此，它们的化学、生物和机械性能仍然可以通过开发新的制备技术来提高。本文报道了通过金属有机化学气相沉积 (MOCVD) 技术在商业钛基底上生长的氧化钛层的表面特征。样品的生物相容性在体外处理时作为暴露时间的函数进行测试。钛基材和氧化物涂层的表面表征是通过使用不同的分析技术进行的。通过X射线光电子能谱（XPS）、扫描电子显微镜（SEM）和扫描隧道显微镜（STM）研究了涂层的表面化学成分和形貌。定量 XPS 分析和表面物理图像显示 MOCVD 沉积的氧化物涂层具有良好的质量（清洁度、均匀性、粗糙度）以及与成骨细胞相互作用引起的表面修饰。 (C) 2001 Elsevier Science B.V. 保留所有权利。
Titanium oxide coatings are normally used for orthopaedic and dental prostheses. Nevertheless, their chemical, biological and mechanical properties can be still improved by the development of new preparation technologies. In this paper a surface characterisation of the titanium oxide layer, grown on commercial Ti substrates by metal organic chemical vapour deposition (MOCVD) technique, is reported. The biocompatibility of the samples is tested upon in vitro treatment as a function of the exposure time. The surface characterisation of the titanium substrate and the oxide coatings is performed by using different analytical techniques. Surface chemical composition and morphology of the coatings are investigated by X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and scanning tunnelling microscopy (STM). Quantitative XPS analysis and surface physical images show a good quality (cleanness, homogeneity, roughness) of the oxide coating deposited by MOCVD and the surface modifications induced by the interaction with osteoblast cells. (C) 2001 Elsevier Science B.V. All rights reserved.