Molecular Biology of Glucocorticoid Signaling
Molecular Biology of Glucocorticoid Signaling
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DOI：
10.1007/978-1-4939-2895-8_2
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发表时间：
2015-01-01
期刊：
影响因子：
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通讯作者：
Jeanneteau, Freddy
中科院分区：
文献类型：
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作者：
Arango-Lievano, Margarita;Lambert, W. Marcus;Jeanneteau, Freddy
糖皮质激素被很好地定义为信号激素，用于编程特定细胞类型和上下文相关的基因表达特征，糖皮质激素控制经验驱动的同素作用。一个统一的模型是，糖皮质激素通过动员细胞能量储存，基因表达谱，以及细胞的电和形态特性的变化，帮助在变化的环境中维持细胞网络的完整性和可塑性。细胞核是它们的主要作用部位，但最近的发现指出，神经元突触的质膜上有额外的基因转录独立功能。糖皮质激素是一种分泌因子，从本质上反映了发育和成年期间来自外部世界的、时间上和区域上的变化。在这篇综述中，我们将列举糖皮质激素及其受体的性质和信号特征，这些受体将它们描述为变态调节因子。用于支持它们在突触中的作用的分子机制将被强调。
Well-defined as signaling hormones for the programming of cell type-specific and context-dependent gene expression signatures, glucocorticoids control experience-driven allostasis. One unifying model is that glucocorticoids help maintaining the integrity and plasticity of cellular networks in changing environments through the mobilization of cellular energy stores, profiling of gene expression, and changes in the electrical and morphological properties of cells. The nucleus is their primary site of action, yet recent discoveries point to additional gene transcription-independent functions at the plasma membrane of neuronal synapses. Glucocorticoids are secreted factors that reflect intrinsically the changes coming from the external world, temporally and regionally, during development and adulthood. In this review, we will enumerate the properties and signaling attributes of glucocorticoids and their receptors that characterize them as allostatic modulators. The molecular mechanisms used to support their role at the synapse will be highlighted.