β-Catenin and ZO-1:: Shuttle molecules involved in tumor invasion-associated epithelial-mesenchymal transition processes
β-Catenin and ZO-1:: Shuttle molecules involved in tumor invasion-associated epithelial-mesenchymal transition processes
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DOI：
10.1159/000101304
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发表时间：
2007-01-01
影响因子：
2.7
通讯作者：
Gilles, Christine
中科院分区：
文献类型：
--
作者：
Polette, Myriam;Mestdagt, Melanie;Gilles, Christine
β-连环蛋白和ZO-1从粘附细胞和紧密连接细胞的胞质/核再定位是与肿瘤侵袭相关的上皮-间质转化（EMT）的常见过程。现在积累的数据表明，这些在质膜和细胞核或胞质溶胶之间穿梭的分子参与信号传导途径，并有助于调节EMT期间开启的基因，如波形蛋白或基质金属蛋白酶-14。版权所有（c）2007 S. Karger AG，巴塞尔。
The cytoplasmic/nuclear relocalization of beta-catenin and ZO-1 from the adherens and tight junctions are common processes of the epithelial-mesenchymal transition (EMT) associated with tumor invasion. Data are now accumulating to demonstrate that these molecules, which shuttle between the plasma membrane and the nucleus or the cytosol, are involved in signaling pathways, and contribute to the regulation of genes such as vimentin or matrix metalloproteinase-14 which are turned on during EMT. Copyright (c) 2007 S. Karger AG, Basel.