Genomic profiles of MALT lymphomas: variability across anatomical sites
Genomic profiles of MALT lymphomas: variability across anatomical sites
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DOI：
10.3324/haematol.2011.040402
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发表时间：
2011-07-01
期刊：
影响因子：
--
通讯作者：
Bertoni, Francesco
中科院分区：
文献类型：
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作者：
Kwee, Ivo;Rancoita, Paola M. V.;Bertoni, Francesco
MALT 淋巴瘤具有共同特征，但重要的差异与特定解剖部位的参与有关，许多可能与生物学有关。为了测试主要涉及的解剖部位特异的遗传改变是否存在，我们对一系列解剖部位的 130 个 MALT 淋巴瘤中通过高密度阵列获得的基因组图谱进行了分析。3 号三体和 18 号三体以及 del(6q23) 的发生频率相似。相反，在涉及眼眶附件的 MALT 淋巴瘤中，6p 时的增益似乎更为常见。胃受累显示出 8q 增益频率较高的趋势。 总之，MALT 淋巴瘤似乎具有一组常见的复发性不平衡基因组改变，与解剖部位无关。这与常见染色体易位的观察结果不同。只有少数改变，例如 6p 处的增益，以及可能的 8q 处的增益，显示出特定解剖部位的优先参与。
MALT lymphomas present common features, but important differences are associated with involvement of specific anatomical sites, many likely contributing to the biology. To test the existence of genetic alterations specific for primary anatomical sites of involvement, genomic profiles obtained with high-density arrays were analyzed in 130 MALT lymphomas across a spectrum of anatomic sites.Trisomies 3 and 18 and del(6q23) occurred at a similar frequency. Instead, gains at 6p appeared significantly more common among MALT lymphomas involving the orbital adnexa. Gastric involvement showed a trend for a higher frequency of 8q gains.In conclusion, MALT lymphomas appear to bear a common set of recurrent unbalanced genomic alterations independent of the anatomical site. This differs from what has been observed for common chromosome translocations. Only a few alterations such as gains at 6p and, possibly, gains at 8q show preferential involvement at specific anatomical sites.