Selective brain cooling increases cortical cerebral blood flow in rats.
Selective brain cooling increases cortical cerebral blood flow in rats.
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选择性脑冷却会增加大鼠皮质脑血流量。
DOI：
10.1152/ajpheart.1993.265.3.h824
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Busto,R
中科院分区：
文献类型：
--
作者：
Kuluz,JW;Prado,R;Chang,J;Ginsberg,MD;Schleien,CL;Busto,R
为了评估选择性脑冷却对皮质脑血流量的影响，我们使用高速风扇降低一氧化二氮麻醉的成年大鼠的脑温度，同时将直肠温度保持在 37-38 摄氏度。在选择性脑冷却过程中，在皮质脑温度为 30.9 +/- 0.5 摄氏度和直肠温度为 30.9 +/- 0.5 摄氏度时，通过激光多普勒血流计测量的皮质脑血流量增加至基线的 215 +/- 26%（平均值 +/- SE）。温度为 37.5 +/- 0.1 摄氏度。复温期间，随着大脑温度升高，皮质脑血流量减少。对低温的脑血管舒张反应可以解释其在脑缺血期间和之后的保护作用。
To evaluate the effect of selective brain cooling on cortical cerebral blood flow, we reduced brain temperature in nitrous oxide anesthetized adult rats using a high speed fan while keeping rectal temperature at 37-38 degrees C. During selective brain cooling, cortical cerebral blood flow, as measured by laser-Doppler flowmetry, increased to 215 +/- 26% (mean +/- SE) of baseline at a cortical brain temperature of 30.9 +/- 0.5 degrees C and a rectal temperature of 37.5 +/- 0.1 degrees C. During rewarming, as brain temperature increased, cortical cerebral blood flow decreased. The cerebral vasodilatory response to hypothermia may explain its protective effects during and after cerebral ischemia.