Integrating Genomics into Healthcare: A Global Responsibility
Integrating Genomics into Healthcare: A Global Responsibility
复制标题
DOI：
10.1016/j.ajhg.2018.11.014
复制
发表时间：
2019-01-03
影响因子：
9.8
通讯作者：
North, Kathryn N.
中科院分区：
文献类型：
--
作者：
Stark, Zornitza;Dolman, Lena;North, Kathryn N.
基因组测序正在迅速过渡到临床实践中，医疗保健系统的实施得到了至少14个国家的大量政府投资的支持，总额超过40亿美元。这些国家基因组医学计划正在推动现实生活条件下的变革，同时解决实施障碍并收集证据以供更广泛采用。我们回顾了英国、法国、澳大利亚和美国国家基因组医学计划的方法多样性和当前进展，并为在国际上共享战略、标准和数据以加速实施提供了路线图。
Genomic sequencing is rapidly transitioning into clinical practice, and implementation into healthcare systems has been supported by substantial government investment, totaling over US$4 billion, in at least 14 countries. These national genomic-medicine initiatives are driving transformative change under real-life conditions while simultaneously addressing barriers to implementation and gathering evidence for wider adoption. We review the diversity of approaches and current progress made by national genomic-medicine initiatives in the UK, France, Australia, and US and provide a roadmap for sharing strategies, standards, and data internationally to accelerate implementation.