The Role of VE-cadherin in Blood-brain Barrier Integrity Under Central Nervous System Pathological Conditions.
The Role of VE-cadherin in Blood-brain Barrier Integrity Under Central Nervous System Pathological Conditions.
复制标题
VE-钙粘蛋白在中枢神经系统病理条件下血脑屏障完整性中的作用。
DOI：
10.2174/1570159x16666180222164809
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发表时间：
2018
影响因子：
5.3
通讯作者：
Dai H
中科院分区：
文献类型：
--
作者：
Li W;Chen Z;Chin I;Chen Z;Dai H
血脑屏障是血液循环和神经组织之间的一层。它在维持神经元实质内脆弱的细胞外微环境中起着关键作用。神经炎性事件可通过干扰黏附连接(AJ)和紧密连接(TJ)而导致血脑屏障失调。VE-钙粘附素作为血管系统中最重要的组成部分之一，专门负责AJ和BBB结构的组装。在这里，我们提出一个综述，其中强调了最近可用的洞察力之间的神经炎症和血脑屏障失调的关系。然后，我们探讨了VE-钙粘蛋白和BBB之间的特定相互作用。最后，我们从实验和临床两个方面讨论了VE-钙粘蛋白在不同神经系统疾病中的变化。了解VE-钙粘蛋白在血脑屏障调节中的作用可能表明，VE-钙粘蛋白可以部分作为神经炎症性疾病的生物标志物，从而为减轻病理条件下的血脑屏障失调和中枢神经系统(CNS)药物释放后血脑屏障的开放开辟新的途径。
The blood-brain barrier (BBB) is a layer between the blood circulation and neural tissue. It plays a pivotal role in maintaining the vulnerable extracellular microenvironment in the neuronal parenchyma. Neuroinflammatory events can result in BBB dysregulation by disturbing adherens junctions (AJs) and tight junctions (TJs). VE-cadherin, as one of the most im-portant components of the vascular system, is specifically responsible for the assembly of AJs and BBB architecture. Here, we present a review, which highlights recently available insights into the relationship between the neuroinflammation and BBB dysregulation. We then explore the specific interaction between VE-cadherin and BBB. Fi-nally, we discuss the changes of VE-cadherin with different neurological diseases from both experimental and clinical stud-ies. An understanding of VE-cadherin in BBB regulation may indicate that VE-cadherin can partially be a biomarker of neu-roinflammation disease and lead to novel approaches for abating BBB dysregulation under pathological conditions and the opening of the BBB following central nervous system (CNS) drug delivery.