Genomic responses to herbal extracts: lessons from in vitro and in vivo studies with an extract of Ginkgo biloba.
Genomic responses to herbal extracts: lessons from in vitro and in vivo studies with an extract of Ginkgo biloba.
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对草药提取物的基因组反应：银杏叶提取物的体外和体内研究的教训。
DOI：
10.1016/s0006-2952(02)01163-2
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发表时间：
2002
影响因子：
5.8
通讯作者：
Gohil,Kishorchandra
中科院分区：
文献类型：
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作者：
Gohil,Kishorchandra
草药提取物是否提供有效的膳食补充剂，以防止转录组的失调？他们能使人类慢性疾病的失调转录组正常化吗？草药提取物的作用是否以组织特异性方式针对特定的分子途径？草药补充剂的作用是可逆的吗？这些问题对致力于了解健康和疾病期间生理学的分子基础的分子营养和医学领域提出了重要挑战。DNA脱氧核苷酸序列编码的分子信息转录为RNA核苷酸序列，在生物体协调适应其不断变化的环境和营养需求方面发挥着至关重要的作用。发病机制是基因组转录缺陷的表现。草药提取物可以针对这些强制性过程。越来越多的信使RNA定量和全面分析工具的可用性提供了强大的手段来理解和识别这些基本过程中的变化。银杏叶提取物的研究表明，提取物影响体外和体内功能不同的基因组的转录。这些观察结果为提取物的生物活性提供了分子证据，并提供了一种分析策略来定义和预测植物化学物质复杂混合物的生理效应。
Do herbal extracts offer effective dietary supplements to prevent deregulation of the transcriptome? Can they normalize deregulated transcriptomes of chronic human diseases? Are the effects of herbal extracts targeted to specific molecular pathways in tissue-specific manner? Are the effects of herbal supplements reversible? These questions pose important challenges to the fields of molecular nutrition and medicine, which are committed to understanding the molecular basis of physiology during health and disease. Transcription of the molecular information encoded in the deoxynucleotide sequences of DNA to the nucleotide sequences of RNA play a vital, causative, role in the coordinated adaptation of the organism to its changing environment and its nutritional needs. Pathogenesis is a manifestation of defects in transcription of the genome. Herbal extracts may target these obligatory processes. Increased availability of tools for quantitative and comprehensive analysis of messenger RNAs offer powerful means to understand and identify changes in these fundamental processes. Studies with the extract of Ginkgo biloba leaves show that the extract affects transcription of functionally diverse groups of genes in vitro and in vivo. The observations offer molecular evidence for bioactivity of the extract and offer an analytical strategy to define and predict physiological effects of complex mixtures of phytochemicals.