Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [99mTc] TRODAT-1
Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [99mTc] TRODAT-1
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DOI：
10.1111/j.1399-5618.2009.00771.x
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发表时间：
2010-02-01
影响因子：
5.4
通讯作者：
Lu, Ru Band
中科院分区：
文献类型：
--
作者：
Chang, Ting Ting;Yeh, Tzung Lieh;Lu, Ru Band
目的：多巴胺与双相情感障碍的病因有关。本研究的目的是探讨纹状体多巴胺转运蛋白（DAT）的可用性在正常胸腺双相patients.Methods：17个药物自由正常胸腺双相患者被招募。结果：与正常对照组相比，正常双相情感障碍患者纹状体DAT的利用率明显增高。结论：正常双相情感障碍患者纹状体DAT的利用率仍高于正常对照组。
Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients.Methods: Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [Tc-99m] TRODAT-1.Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT.Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.