BRAIN Initiative: Cutting-Edge Tools and Resources for the Community
BRAIN Initiative: Cutting-Edge Tools and Resources for the Community
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DOI：
10.1523/jneurosci.1169-19.2019
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发表时间：
2019-10-16
影响因子：
5.3
通讯作者：
Koroshetz, Walter
中科院分区：
文献类型：
--
作者：
Litvina, Elizabeth;Adams, Amy;Koroshetz, Walter
NIH BRAIN（Brain Research through Advancing Innovative Neurotechnologies）计划的总体目标是通过技术创新来促进对健康和患病脑回路功能的理解。这一目标的核心原则包括验证和传播从BRAIN资助的研究中出现的无数创新技术、工具、方法和资源。创新者、BRAIN资助机构和非联邦合作伙伴正在共同努力制定策略，使这些产品可供科学界使用、获取和访问。在这里，我们描述了支持BRAIN技术传播的几个早期策略。我们的目标是促进与神经科学研究和资助界，跨学科合作者和学员的对话，讨论将突破性研究产品培养成成熟，综合和适应性强的研究系统的现有和未来机会。沿着伴随着神经科学学会2019年小型研讨会，“脑倡议：尖端工具和资源的社区，”我们重点介绍了几个脑研究团队的工作，他们正在为神经科学界提供工具，技术和服务。这些工具在多个分析层面访问神经回路，从亚细胞组成到全脑网络连接，包括以下内容：基于EM和荧光的连接组学的集成系统，免疫标记能力的进步，以及记录和分析功能连接的资源。研究人员描述了他们为社区提供的资源将如何有助于实现NIH BRAIN计划的目标。最后，除了庆祝这些BRAIN资助的研究人员的贡献外，小型研讨会还将展示BRAIN计划在尖端技术和资源方面投资的更广泛多样性。
The overarching goal of the NIH BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative is to advance the understanding of healthy and diseased brain circuit function through technological innovation. Core principles for this goal include the validation and dissemination of the myriad innovative technologies, tools, methods, and resources emerging from BRAIN-funded research. Innovators, BRAIN funding agencies, and non-Federal partners are working together to develop strategies for making these products usable, available, and accessible to the scientific community. Here, we describe several early strategies for supporting the dissemination of BRAIN technologies. We aim to invigorate a dialogue with the neuroscience research and funding community, interdisciplinary collaborators, and trainees about the existing and future opportunities for cultivating groundbreaking research products into mature, integrated, and adaptable research systems. Along with the accompanying Society for Neuroscience 2019 Mini-Symposium, "BRAIN Initiative: Cutting-Edge Tools and Resources for the Community," we spotlight the work of several BRAIN investigator teams who are making progress toward providing tools, technologies, and services for the neuroscience community. These tools access neural circuits at multiple levels of analysis, from subcellular composition to brain-wide network connectivity, including the following: integrated systems for EM- and florescence-based connectomics, advances in immunolabeling capabilities, and resources for recording and analyzing functional connectivity. Investigators describe how the resources they provide to the community will contribute to achieving the goals of the NIH BRAIN Initiative. Finally, in addition to celebrating the contributions of these BRAIN-funded investigators, the Mini-Symposium will illustrate the broader diversity of BRAIN Initiative investments in cutting-edge technologies and resources.