NEOPLASTIC AND OTHER DISEASES IN FISH IN RELATION TO TOXIC-CHEMICALS - AN OVERVIEW
NEOPLASTIC AND OTHER DISEASES IN FISH IN RELATION TO TOXIC-CHEMICALS - AN OVERVIEW
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DOI：
10.1016/0166-445x(88)90006-9
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发表时间：
1988-01-01
影响因子：
4.5
通讯作者：
ROUBAL, WT
中科院分区：
文献类型：
--
作者：
MALINS, DC;MCCAIN, BB;ROUBAL, WT
在普吉湾进行了为期5年的实地研究，调查底栖海洋鱼类肝肿瘤的发病率之间的病因关系，重点是英国唯一（Parophrys vetulus），和沉积物和底鱼中有毒化学物质的浓度。肝脏肿瘤的患病率与（1）沉积物中芳烃含量和（2）胆汁中芳烃代谢产物的浓度之间存在统计学显著相关性;肝脏病变的英国鳎肝脏微粒体中氮杂环的N-氧衍生物（自由基）的浓度与无肝脏病变的英国鳎肝脏微粒体中氮杂环的N-氧衍生物（自由基）的浓度之间也存在显著差异。这些N-oxyl自由基显然是代谢衍生的复杂套房的氮杂环存在于普吉湾environments.Recent证据表明，芳香族自由基（可能衍生物的芳烃）也可能绑定到肝DNA分离英国唯一的肝肿瘤收集在几个污染地区的普吉湾。迄今为止，尚未从参考区的鱼类和污染区的无病变鱼类中获得外源性物质与DNA相互作用的证据。各种实验室研究旨在评估肝肿瘤的病因也产生了证据，这是一致的，认为高分子量的芳烃在肝肿瘤的病因底栖fish.Associations之间的化学品暴露和疾病的其他海洋物种从南加州和波士顿港的底栖fish. Associations发挥了重要作用。还介绍了某些底栖淡水物种的肝脏和皮肤肿瘤与沉积物相关化学品之间的类似关系。
Field studies were conducted over a 5-year period in Puget Sound to investigate etiological relationships between prevalences of hepatic neoplasms in bottom-dwelling marine fish, with emphasis on English sole (Parophrys vetulus), and concentrations of toxic chemicals in sediments and bottom fish. Statistically significant correlations were found between prevalences of hepatic neoplasms and (1) sediment concentrations of aromatic hydrocarbons, and (2) concentrations of metabolites of aromatic compounds in the bile.A significant difference was also found between the concentrations of N-oxyl derivatives of nitrogen heterocycles (free radicals) in liver microsomes of English sole with liver lesions compared to sole without liver lesions. These N-oxyl free radicals were apparently metabolically derived from complex suites of nitrogen heterocycles present in Puget Sound environments.Recent evidence suggests that aromatic free radicals (possibly derivatives of aromatic hydrocarbons) may also be bound to hepatic DNA isolated from English sole with liver neoplasms collected in several polluted areas of Puget Sound. Such evidence for xenobiotic-DNA interactions has thus far not been obtained for fish from reference areas and for lesion-free fish from polluted areas. Various laboratory studies designed to evaluate the etiology of the liver neoplasms have also yielded evidence that is consistent with the view that high molecular weight aromatic hydrocarbons play a significant role in the etiology of hepatic tumors in the bottom-dwelling fish.Associations between chemical exposures and diseases in other marine species from southern California and Boston Harbor are also discussed. Similar relationships between liver and skin neoplasms in selected bottom feeding fresh water species and sediment-associated chemicals are also presented.