Citrate in pediatric CNS tumors?
Citrate in pediatric CNS tumors?
复制标题
DOI：
10.3174/ajnr.a1018
复制
发表时间：
2008-05-01
影响因子：
3.5
通讯作者：
Bluml, S.
中科院分区：
文献类型：
--
作者：
Seymour, Z. A.;Panigrahy, A.;Bluml, S.
背景和目的：在从儿科脑肿瘤获得的体内 MR 光谱的子集中，我们观察到了一个未指定的峰。本研究的目的是确定该化学物质的来源以及该化学物质在各种儿科脑肿瘤中的普遍性和浓度。 材料和方法：对 85 名脑肿瘤患者和 469 名对照受试者的单体素点分辨光谱 (PRESS) 光谱进行了分析。柠檬酸盐似乎是一个可能的候选者，柠檬酸盐的模型谱被添加到代谢物的基础组中，以便使用 LCModel 软件进行自动处理。测定了柠檬酸盐的绝对“表观”浓度和 Cramer-Rao 下限 (CRLB)（检测可靠性指标）。结果：在 85 名 CRLB 低于 25% 的患者中，有 26 名检测到“表观”柠檬酸盐。弥漫性内在脑干胶质瘤 (DIBSG) 的平均浓度最高（所有受试者为 4.0 +/- 1.1 mmol/kg），12 名患者中有 8 名的 CRLB 低于 25%。柠檬酸盐显着减少（P
BACKGROUND AND PURPOSE: In a subset of in vivo MR spectra acquired from pediatric brain tumors, we have observed an unassigned peak. The goal of this study was to determine the molecule of origin, and the prevalence and concentration of this chemical in various pediatric brain tumors.MATERIALS AND METHODS: Single-voxel point-resolved spectroscopy (PRESS) spectra from 85 patients with brain tumors and 469 control subjects were analyzed. Citrate seemed to be a likely candidate, and model spectra of citrate were added to the basis set of metabolites for automated processing with use of LCModel software. Absolute "apparent" concentrations of citrate and the Cramer-Rao lower bounds (CRLB), indicators for the reliability of detection, were determined.RESULTS: "Apparent" citrate was detected in 26 of 85 patients with CRLB of less than 25%. Diffuse intrinsic brain stem glioma (DIBSG) had the highest mean concentration (4.0 +/- 1.1 mmol/kg in all subjects), and 8 of 12 patients had CRLB less than 25%. A significant reduction of citrate (P