Asynchronous transmitter release: control of exocytosis and endocytosis at the salamander rod synapse.
Asynchronous transmitter release: control of exocytosis and endocytosis at the salamander rod synapse.
复制标题
异步递质释放：控制蝾螈杆突触的胞吐作用和内吞作用。
DOI：
10.1113/jphysiol.1996.sp021360
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Schwartz,EA
中科院分区：
文献类型：
--
作者：
Rieke,F;Schwartz,EA
1. 我们利用钙离子成像、电容测量和钙离子缓冲液光解相结合的方法研究了蝾螈杆突触末端的胞外作用和内吞作用。2. 暗静息电位下的平均细胞质Ca2+浓度为2‐4微米。3. 平均胞质Ca2+浓度为2‐4微米时，维持了高的连续胞吐和内吞率。4. 胞吐速率变化后，在不到0.7 s内吞速率发生代偿性变化。5. 杆状突触中的囊泡循环专门用于分级传递，与先前描述的释放同步传递脉冲的突触不同。
1. We have studied exocytosis and endocytosis in the synaptic terminal of salamander rods using a combination of Ca2+ imaging, capacitance measurement and the photolysis of Ca2+ buffers. 2. The average cytoplasmic Ca2+ concentration at the dark resting potential was 2‐4 microM. 3. An average cytoplasmic Ca2+ concentration of 2‐4 microM maintained a high rate of continuous exocytosis and endocytosis. 4. Changes in the rate of exocytosis were followed in less than 0.7 s by compensatory changes in the rate of endocytosis. 5. Vesicle cycling in the rod synapse is specialized for graded transmission and differs from that previously described for synapses that release synchronized bursts of transmitter.