The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants
The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants
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DOI：
10.1002/eji.200940172
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发表时间：
2010-03-01
影响因子：
5.4
通讯作者：
Lavelle, Ed C.
中科院分区：
文献类型：
--
作者：
Harris, James;Sharp, Fiona A.;Lavelle, Ed C.
佐剂对于增强和引导对疫苗抗原的免疫是必不可少的。临床使用的大多数佐剂是颗粒，但它们如何驱动先天性和适应性免疫反应尚不清楚。最近的一个主要进展是证明了颗粒佐剂促进NLRP 3炎性体的活化。这种激活的潜在机制已经部分解决，NLRP 3在颗粒清除剂诱导的适应性免疫中的作用是目前非常感兴趣的主题。
Adjuvants are essential for enhancing and directing immunity to vaccine antigens. Most adjuvants in clinical use are particulates, but how they drive innate and adaptive immune responses is unclear. A major recent advance was the demonstration that particulate adjuvants promote activation of the NLRP3 inflammasome. The mechanisms underlying this activation have been partly resolved and the role of NLRP3 in particulate adjuvant-induced adaptive immunity is currently the subject of intense interest.