Analysis of mammographic density and breast cancer risk from digitized mammograms
Analysis of mammographic density and breast cancer risk from digitized mammograms
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DOI：
10.1148/radiographics.18.6.9821201
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发表时间：
1998-11-01
期刊：
影响因子：
5.5
通讯作者：
Boyd, NF
中科院分区：
文献类型：
--
作者：
Byng, JW;Yaffe, MJ;Boyd, NF
为了评估乳腺摄影密度和乳腺癌风险之间的关系，开发了一种简单的，称为交互式阈值的辅助技术，该技术允许使用计算机工作站对乳腺摄影密度进行可靠的定量评估。使用该技术有助于确认乳腺摄影密度是乳腺癌最强的风险因素之一，并且存在于大部分乳腺癌病例中。乳房X线摄影密度和乳腺癌风险之间的密切关系表明，通过识别与乳房X线摄影密度组织相关的因素并确定这些组织如何随着这些因素的变化而变化，可以更好地了解乳腺癌的原因。此外，由于可以修改乳房X线摄影密度，因此乳房X线摄影密度也可能是制定和监测潜在预防策略的良好工具。正在进行的研究领域包括通过比较双胞胎的密度测量值来评估乳房X线摄影密度的潜在遗传成分，并了解密度相对于年龄、绝经状态、外源性激素使用和暴露于环境致癌物的变化。此外，正在开展工作，以确定乳房X线摄影以外的成像方式的测量值，并将这些测量值与乳腺癌风险直接联系起来。
To evaluate the association between mammographic density and breast cancer risk, a simple, observer-assisted technique called interactive thresholding was developed that allows reliable quantitative assessment of mammographic density with use of a computer workstation Use of this technique helps con firm that mammographic density is one of the strongest risk factors for breast cancer and is present in a large proportion of breast cancer cases. The strong relationship between mammographic density and breast cancer risk suggests that the causes of breast cancer may be better understood by identifying the factors associated with mammographically dense tissue and determining how such tissue changes as these factors vary, Furthermore, because it can be modified, mammographic density may also be a good vehicle for the development and monitoring of potential preventive strategies, Areas of ongoing investigation include evaluating a potential genetic component of mammographic density by comparing density measurements in twins and understanding changes in density relative to age, menopausal status, exogenous hormone use, and exposure to environmental carcinogens. In addition, work is ongoing to establish measurements from imaging modalities other than mammography and to relate these measurements directly to breast cancer risk.