DIMETHYL SULFOXIDE .2.
DIMETHYL SULFOXIDE .2.
复制标题
DOI：
10.1001/jama.1965.03090110061015
复制
发表时间：
1965-01-01
影响因子：
--
通讯作者：
KLIGMAN, AM
中科院分区：
文献类型：
--
作者：
KLIGMAN, AM
二甲基亚砜（DMSO）对成年男性皮肤和健康的生理和病理影响进行了广泛的研究。浓度在70%及以上的二甲基亚砜浓缩溶液，可显著增加各种染料、类固醇和止汗剂的渗透。渗透的增强不依赖于对角质层的不可逆损伤。2%盐酸普鲁卡因和盐酸利多卡因溶于90%二甲基亚砜的溶液不能实现皮肤麻醉。二甲亚砜在应用部位具有有效的组胺释放特性。循环嗜碱性粒细胞减少后，广泛的局部使用，但仍在正常范围内。二甲亚砜具有温和的抗真菌和抗菌作用。浓缩溶液可将常驻微生物菌群减少95%。二甲亚砜是一种很有前途的车辆抗真菌剂在治疗癣感染。当注射时，二甲亚砜减少可溶性物质从皮肤的清除，主要是通过减少通过真皮的扩散。90%二甲基亚砜可促进盐水风团的吸收。二甲亚砜（90%）既不妨碍也不帮助实验性热烧伤，接触性皮炎和紫外线烧伤。二甲亚砜（90%）在健康受试者的躯干上每日一次给药6个月时没有全身性损伤。每日两次应用90%二甲基亚砜会导致某些受试者出现轻度鳞屑性皮炎。皮肤迅速变得耐受二甲基亚砜的刺激作用，即使在连续暴露。封闭性暴露导致外表皮死亡，随后尽管持续应用，但仍快速再生。
The physiological and pathological effects of dimethyl sulfoxide (DMSO) on the skin and health of adult men was extensively studied. Concentrated solutions of dimethyl sulfoxide, 70% and above, markedly increase the penetration of various dyes, steroids, and antiperspirants. The enhancement of penetration is not dependent on irreversible damage to the horny layer. Skin anesthesia was not achieved by 2% solutions of procaine hydrochloride and lidocaine hydrochloride in 90% dimethyl sulfoxide. Dimethyl sulfoxide possesses potent histamineliberating properties at the site of application. The circulating basophils are decreased after extensive topical use but remain within normal limits. Dimethyl sulfoxide is mildly antifungal and antibacterial. Concentrated solutions reduce the resident microflora by 95%. Dimethyl sulfoxide is a promising vehicle for antifungal agents in the treatment of ringworm infections. When injected, dimethyl sulfoxide reduces the clearance of soluble substances from the skin, chiefly by reducing diffusions through the dermis. The resorption of saline wheals is promoted by 90% dimethyl sulfoxide. Dimethyl sulfoxide (90%) neither hindered nor helped experimental thermal burns, contact dermatitis, and ultraviolet burns. Dimethyl sulfoxide (90%) was not systemically injurious when applied once daily to the trunks of healthy subjects for 6 months. Twice daily applications of 90% dimethyl sulfoxide cause a mild scaling dermatitis in certain subjects. The skin rapidly becomes tolerant to the irritant effects of dimethyl sulfoxide even upon continuous exposure. Occlu-sive exposure causes death of the outer epidermis, followed by rapid regeneration despite continued application.