Synaptic Regulation of Metabolism.
Synaptic Regulation of Metabolism.
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DOI：
10.1007/978-981-13-1286-1_4
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发表时间：
2018
影响因子：
--
通讯作者：
Jie Xu;Christopher Bartolome;D. Kong
中科院分区：
文献类型：
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作者：
Jie Xu;Christopher Bartolome;D. Kong
大脑中的神经元，特别是下丘脑中的神经元，对于维持全身代谢稳态至关重要。它们的功能障碍或失调可导致各种代谢疾病，包括饮食失调、肥胖和糖尿病。除了激素和肽能调节，越来越多的证据表明，这些神经元受到突触调节，这在很大程度上被忽视了。在本章中，我们重点介绍了下丘脑神经元的突触神经传递，并总结了目前的知识突触可塑性在维持能量平衡。突触调制从事循环激素也进行了讨论。
Neurons in the brain, particularly those in the hypothalamus, are essential for the maintenance of whole-body metabolic homeostasis. Dysfunctions or dysregulations of them can result in various metabolic diseases, including eating disorders, obesity, and diabetes. In addition to hormonal and peptidergic regulation, accumulating evidence has shown that these neurons are subject to synaptic regulation, which has been largely overlooked. In this chapter, we focus on synaptic neurotransmission of hypothalamic neurons and summarize current knowledge of synaptic plasticity in the maintenance of energy balance. Synaptic modulation engaged by circulating hormones is also discussed.