Novel 2019-coronavirus on new year's Eve.
Novel 2019-coronavirus on new year's Eve.
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DOI：
10.4103/ijmm.ijmm_20_54
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发表时间：
2019-10
影响因子：
1.6
通讯作者：
Singh MP
中科院分区：
文献类型：
--
作者：
Gupta P;Goyal K;Kanta P;Ghosh A;Singh MP
一种新病毒正在中国武汉市爆发，导致肺炎样聚集，这一世界末日般的爆发令世界瞩目。疫情于2020年除夕确认，自那以后就没有边界。这一数字已经超过了严重急性呼吸系统综合征（SARS）和中东呼吸系统综合征（MERS），而且还在不断上升。作为一种RNA病毒，由于RNA依赖性RNA聚合酶的低校对能力，它具有突变的倾向。逐步突变导致病毒逐渐溢出，在跨越物种间界面后，病毒已经适应了稳定的人际传播。如果所谓的“超级传播事件”随着时间的推移而出现，由严重急性呼吸道综合征冠状病毒（CoV）-2（SARS-CoV-2）引起的疾病可能会更加致命。最近的研究表明，SARS-CoV-2与穿山甲相关冠状病毒的同源性最高为99%，因此它们可以作为潜在的中间宿主。印度正迅速应对紧急情况，自2020年3月25日起全国处于封锁状态，以确保保持社交距离。所有国际航班都被封锁，旅客在机场和海港通过热传感器进行筛查，建议隔离14天。截至2020年3月22日，全国共有345名患者检测呈阳性，其中6人死亡。目前没有特定的抗CoV药物可用。患者正在接受蛋白酶抑制剂、remdesivir、氯喹、血管紧张素转换酶2抑制剂、伊维菌素、sar和tocilizumab的治疗，尽管这些药物都没有得到食品和药物管理局的批准，正在进行试验。社交距离、隔离、咳嗽礼仪、正确洗手、清洁和消毒表面等预防措施是遏制这种病毒传播的主要措施。本综述强调了在印度的情况下，新的SARS-CoV-2的更新。
An ongoing apocalyptic outbreak of a new virus causing pneumonia-like clusters in Wuhan city, China, has gleamed the world. The outbreak, confirmed on the New Year’s Eve 2020, has known no boundaries since then. The number has surpassed that of Severe Acute Respiratory Syndrome (SARS) and Middle East respiratory syndrome (MERS), and is uninterruptedly escalating. Being an RNA virus, it has a propensity to mutate due to the low proofreading capacity of RNA-dependent RNA polymerase. Step-wise mutations have led to the gradual spillover of virus and after crossing the inter-species interface, the virus has adapted itself for a stable human-to-human transmission. The disease caused by severe acute respiratory syndrome coronavirus (CoV)-2 (SARS-CoV-2) can prove deadlier if the so-called ‘super-spreading events’ emerge with time. Recent research has shown the maximum homology of 99% of SARS-CoV-2 to pangolins associated coronavirus, owing to which these can serve as potential intermediate host. India is responding swiftly to the emergency situation, and the whole of the country is under lockdown since 25 March 2020, to ensure social distancing. All the international flights are padlocked and the travellers are being screened at airports and seaports via thermal sensors, and quarantine for a period of 14 days is recommended. Three hundred and forty-five patients across the country tested positive with six fatalities as of 22 March 2020. No specific anti-CoV drugs are currently available. Patients are being treated with protease drugs are inhibitors, remdesivir, chloroquine, angiotensin-converting enzyme 2 inhibitors, ivermectin, sarilumab and tocilizumab, though none of these is Food and Drug Administration approved and are undergoing trials. Preventive measures such as social distancing, quarantine, cough etiquettes, proper hand washing, cleaning and decontaminating the surfaces are the mainstay for curbing the transmission of this virus. The present review highlights the update of novel SARS-CoV-2 in context to the Indian scenario.