Anti-inflammatory, antioxidant and hepatoprotective effects of Thunbergia laurifolia Linn. on experimental opisthorchiasis
Anti-inflammatory, antioxidant and hepatoprotective effects of Thunbergia laurifolia Linn. on experimental opisthorchiasis
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DOI：
10.1007/s00436-012-2846-5
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发表时间：
2012-07-01
影响因子：
2
通讯作者：
Sudsarn, Pakkayanee
中科院分区：
文献类型：
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作者：
Wonkchalee, Orasa;Boonmars, Thidarut;Sudsarn, Pakkayanee
Thunbergia laurifolia Linn（Rang Chuet）具有抗氧化和抗炎特性以及抗癌活性。本研究的目的是评价T. laurifolia在减轻感染人类肝吸虫后睾吸虫的叙利亚仓鼠的病理变化引起的炎症中的作用。N-亚硝基二甲胺（NDMA）组给予N-亚硝基二甲胺（NDMA）;月桂叶。光镜下观察组织病理学变化，肝功能检测丙氨酸转氨酶（ALT）和碱性磷酸酶（ALP），肾功能检测血尿素氮（BUN）和肌酐。新鲜和干燥的Rang Chuet解决方案的抗氧化作用进行了观察。组织病理学变化的分析表明，抗炎特性，无论是在O。通过减少肝胆管周围炎性细胞的聚集，如由经处理的叙利亚仓鼠中的正常血清ALT、ALP、BUN和肌酸酐水平所指示的，可以抑制肝细胞感染或NDMA施用。本研究发现，新鲜和干燥的Rang Chuet溶液明显减少了O。与总抗氧化能力相关。这些发现表明T. laurifolia具有抗氧化和抗炎特性，其应用可能有助于预防炎症过程，炎症过程是O. Viverrini相关胆管癌（CCA）。
Thunbergia laurifolia Linn (Rang Chuet) possesses antioxidant and anti-inflammatory properties as well as anticancer activities. The aim of the present study was to evaluate the efficacy of T. laurifolia in reducing inflammation from pathological changes in Syrian hamsters infected with the human liver fluke Opisthorchis viverrini. Hamster groups were also administered N-nitrosodimethylamine (NDMA) and treated with T. laurifolia. Light microscopic observation of histopathological changes, liver function tests for alanine transaminase (ALT) and alkaline phosphatase (ALP) and kidney function tests for blood urea nitrogen (BUN) and creatinine were performed. Antioxidant effects of both fresh and dried Rang Chuet solutions were observed. Analysis of the histopathological changes showed anti-inflammatory properties, both in the case of O. viverrini infection or with NDMA administration, by reducing the aggregation of inflammatory cells surrounding the hepatic bile ducts as indicated by normal serum ALT, ALP, BUN and creatinine levels in treated Syrian hamsters. The present study found that fresh and dried Rang Chuet solutions clearly reduced the inflammatory cells in both O. viverrini-infected and NDMA-administered groups and was correlated with the total antioxidant capacity. These findings suggest that T. laurifolia possesses antioxidant and anti-inflammatory properties and that its application may be useful for prevention of the inflammatory process, one of the risk factors of O. viverrini-associated cholangiocarcinoma (CCA).