Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activities
Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activities
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DOI：
10.1021/np0680073
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发表时间：
2006-08-25
影响因子：
5.1
通讯作者：
Ando, Masayoshi
中科院分区：
文献类型：
--
作者：
Zhao, Ming;Zhang, Shujun;Ando, Masayoshi
从夹竹桃（Nerium oleander）叶的乙酸乙酯提取物中分离得到两个新的蒲公英甾烷型三萜，20 β，28-环氧-28 R-甲氧基蒲公英甾烷-3 β-醇（1）和20 β，28 α-环氧蒲公英-21-烯-3 β-醇（2），以及熊烷型三萜，28-降-熊-12-烯-3 β，17 β-二醇（3）和3 β-羟基乌苏-12-烯-28-醛（4）。化合物1和2的结构根据它们的光谱数据确定。基于对细胞间粘附分子-1（ICAM-1）的诱导的抑制活性，检测1-4的抗炎活性。评价1-4对四种人细胞系A-549、WI-38、VA-13和HepG 2细胞的细胞毒性活性。
Two new taraxasterane-type triterpenes, 20 beta,28-epoxy-28R-methoxytaraxasteran-3 beta-ol (1) and 20 beta,28 alpha-epoxytaraxaster-21-en-3 beta-ol ( 2), were isolated from an ethyl acetate extract of the leaves of Nerium oleander, together with ursane-type triterpenes, 28-nor-urs-12-ene-3 beta, 17 beta-diol (3) and 3 beta-hydroxyurs- 12-en-28-aldehyde (4). The structures of 1 and 2 were established on the basis of their spectroscopic data. Anti-inflammatory activity of 1-4 was examined on the basis of inhibitory activity against the induction of intercellular adhesion molecule-1 (ICAM-1). Cytotoxic activity of 1-4 was evaluated against four human cell lines, A-549, WI-38, VA-13, and HepG2 cells.