The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder.

The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder.
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DOI:
10.1016/j.pscychresns.2014.04.011
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发表时间:
2014-09-30
影响因子:
11.3
通讯作者:
DelBello MP
DelBello MP
中科院分区:
医学2区
文献类型:
--
作者:
Schneider MR;Klein CC;Weber W;Bitter SM;Elliott KB;Strakowski SM;Adler CM;DelBello MP

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本初步研究探讨了在功能性磁共振成像(fMRI)过程中,11名躁狂青年双相情感障碍患者在执行持续注意力任务(连续执行任务-相同配对版本)期间接受卡马西平缓释(XR)治疗的神经功能影响。所有患者均接受基线fMRI检查,10例患者在终点时再次扫描。9名人口统计学匹配的正常青年,扫描一次,作为对照。卡马西平-XR治疗与右侧Brodmann 10区激活正常化相关。这些结果表明,卡马西平XR治疗可以纠正青少年躁狂症的前额功能障碍。
This preliminary study investigated the neurofunctional effects of carbamazepine-extended release (XR) treatment in 11 manic youth with bipolar disorder during performance of a sustained attention task, the Continuous Performance Task – Identical Pairs version, during functional magnetic resonance imaging (fMRI). All patients underwent baseline fMRI, and 10 patients were scanned again at endpoint. Nine demographically matched normal youth, who were scanned once, served as controls. Carbamazepine-XR treatment was associated with normalization of activation in right Brodmann Area 10. These results suggest that carbamazepine-XR treatment may correct prefrontal dysfunction in adolescent mania.
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