Synthesis of quinine and quinidine using sulfur ylide-mediated asymmetric epoxidation as a key step
Synthesis of quinine and quinidine using sulfur ylide-mediated asymmetric epoxidation as a key step
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DOI：
10.1016/j.tetasy.2010.04.046
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发表时间：
2010-07-14
影响因子：
--
通讯作者：
Aggarwal, Varinder K.
中科院分区：
文献类型：
--
作者：
Arshad, Muhammad;Fernandez, M. Alejandro;Aggarwal, Varinder K.
介绍了合成奎宁和奎尼丁的关键步骤，甲基喹啉醛与手性硫酰化物的环氧化反应。环氧化反应在试剂控制下进行，具有高选择性和高收率。讨论了硫化物和硫化物取代基对反应立体化学结果的影响。(C) 2010 Elsevier Ltd.版权所有。
The epoxidation of meroquinene aldehyde with a chiral sulfur ylide as the key step in the synthesis of quinine and quinidine is described. The epoxidation reactions proceed under reagent control with high selectivity and good yield. The effect of sulfide and ylide substituents on the stereochemical outcome of the reaction is discussed. (C) 2010 Elsevier Ltd. All rights reserved.