Chinese herbal medicine for assisted reproduction technology A protocol for a systematic review and meta-analysis.
Chinese herbal medicine for assisted reproduction technology A protocol for a systematic review and meta-analysis.
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中草药辅助生殖技术系统评价和荟萃分析方案。
DOI：
10.1097/md.0000000000022009
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发表时间：
2020
期刊：
影响因子：
1.6
通讯作者：
Wang Ying
中科院分区：
文献类型：
--
作者：
Xie Liangzhen;Li Jian;Li Yan;Wang Bingmei;Xie Chunyu;Xia Qing;Zhang Zhigang;Wang Ying
背景：人类辅助生殖技术（ART）已成为全世界不孕不育治疗的重要组成部分，包括IVF、ICSI、胚胎培养、胚胎冷冻保存等。在中国和东亚，中草药（CHM）已被用于治疗多种疾病，并提高了接受ART治疗的不孕夫妇的活产成功率。本研究的目的是评估中草药对接受ART的女性的效果和安全性。方法：检索Cochrane Library、MEDLINE、EMBASE、CNKI、VIP、CBM和WANGFANG。如果招募接受ART的受试者来评估中草药的效果和安全性，则所有随机对照试验都将被纳入。主要结果是活产。两位作者将独立扫描所有潜在文章，提取数据并使用 Cochrane 偏倚风险工具评估偏倚风险。根据Cochrane Collaboration的指南，所有分析将由RevMan 5.3软件进行。二分变量将表示为 RR，置信区间为 95%，连续变量将报告为 MD，置信区间为 95%。如果可能，将进行固定或随机效应模型，并使用 GRADE 评估累积证据的置信度。结果：本研究将评估中草药对接受 ART 的女性的效果和安全性。结论：本研究将评估中草药对接受 ART 的女性的效果和安全性，并为临床决策提供帮助。1 背景 人类辅助生殖技术（ART）自 2010 年出现以来，已成为不孕症治疗的重要组成部分。 20世纪70年代[1-3]体外受精（IVF）、卵胞浆内单精子注射（ICSI）、胚胎培养、胚胎冷冻保存等辅助生殖技术的广泛应用，为无数400万不孕夫妇带来了希望，全球ART的活产总数从14,507例增加到76,930例，增加了五倍多。[4]但目前 ART 的成功率并不高，仍徘徊在 30%～40% 左右。 [5-8] 导致 ART 妇女妊娠率低的主要原因包括卵子质量差、卵巢功能下降、子宫内膜容受性下降以及控制性过度促排卵导致先兆流产率较高等。
Background:Human assisted reproductive technology (ART) has become an important part of infertility treatments throughout the world, including IVF, ICSI, embryo culture, and embryo cryopreservation. In China and East Asia, Chinese herbal medicine (CHM) has been used to treat various diseases and improves the success chance of live birth among infertile couples undergoing ART treatment. The aim of this study is to assess the effect and safety of Chinese herbal medicine among women undergoing ART.Methods:Cochrane Library, MEDLINE, EMBASE, CNKI, VIP, CBM and WANGFANG will be searched. All randomized controlled trials will be included if they recruited participants undergoing ART for assessing the effect and safety of Chinese herbal medicine. Primary outcomes will be live birth. Two authors will independently scan all the potential articles, extract the data and assess the risk of bias using Cochrane tool of risk of bias. Based on the guideline of Cochrane Collaboration, all analysis will be performed by RevMan 5.3 software. Dichotomous variables will be expressed as RR with 95% CIs and continuous variables will be reported as MD with 95% CIs. If possible, a fixed or random effects models will be conducted and the confidence of cumulative evidence will be assess using GRADE.Results:This study will be to assess the effect and safety of Chinese herbal medicine among women undergoing ART.Conclusions:This study will assess the effect and safety of Chinese herbal medicine among women undergoing ART and move forward to help inform clinical decisions.1 BackgroundHuman assisted reproductive technology (ART) has become an important part of infertility treatments since it emerged in the 1970s.[1–3] The widespread application of assisted reproductive technology, such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), embryo culture, and embryo cryopreservation, has delivered hope to countless 4 million infertile couples and the total number of live births attributable to ART have increased more than fivefold from 14,507 to 76,930 throughout the world.[4] But the success rate of ART is not high at present, still hovering around 30% to 40%.[5–8] The main reasons lead to low pregnancy rate among women undergoing ART including poor egg quality, decreased ovarian function, decreased endometrial receptivity and higher rate of threatened abortion caused by controlled ovarian hyperstimulation.