Molecular signaling in feather morphogenesis
Molecular signaling in feather morphogenesis
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DOI：
10.1016/j.ceb.2006.10.009
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发表时间：
2006-12-01
影响因子：
7.5
通讯作者：
Chuong, Cheng-Ming
中科院分区：
文献类型：
--
作者：
Lin, Chih-Min;Jiang, Ting Xin;Chuong, Cheng-Ming
近年来，羽毛的发育和再生受到了人们的广泛关注，主要表现在以下几个方面。第一，模式形成。精致的空间排列为解码形态发生规则提供了一个简单的模型。第二，干细胞生物学。在每一次蜕皮中，一些干细胞必须重建整个上皮器官，这为如何从生理上再生器官提供了很多知识。第三，进化与发展（“进化-发展”）。在中国发现有羽毛的恐龙化石引起了人们对羽毛起源和进化的热情询问。在羽毛形态发生的五个连续阶段：大模式、微模式、芽内形态发生、毛囊形态发生和再生循环的阐明方面取得了进展。
The development and regeneration of feathers have gained much attention recently because of progress in the following areas. First, pattern formation. The exquisite spatial arrangement provides a simple model for decoding the rules of morphogenesis. Second, stem cell biology. In every molting, a few stem cells have to rebuild the entire epithelial organ, providing much to learn on how to regenerate an organ physiologically. Third, evolution and development ('Evo-Devo'). The discovery of feathered dinosaur fossils in China prompted enthusiastic inquiries about the origin and evolution of feathers. Progress has been made in elucidating feather morphogenesis in five successive phases: macro-patterning, micro-patterning, intra-bud morphogenesis, follicle morphogenesis and regenerative cycling.