Neutralization of the adaptor protein PAG by monoclonal antibody limits murine tumor growth.
Neutralization of the adaptor protein PAG by monoclonal antibody limits murine tumor growth.
复制标题
DOI：
10.1016/j.omtm.2022.10.012
复制
发表时间：
2022-12-08
期刊：
影响因子：
--
通讯作者：
Mor, Adam
中科院分区：
文献类型：
--
作者：
Strazza, Marianne;Moore, Emily K.;Adam, Kieran;Azoulay-Alfaguter, Inbar;Mor, Adam
The transmembrane adaptor phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG) is phosphorylated in T cells downstream of PD-1 signaling and contributes to the resulting functional inhibition of multiple cellular processes. Furthermore, PAG expression is negatively correlated with survival in multiple human tumors and is a driver of murine tumor growth and immune evasion. Here we develop an antibody that targets the extracellular domain of human PAG, with cross-reactivity to murine PAG. We demonstrate that this antibody binds to extracellular PAG on intact cells and affects T cell activation. Finally, we show that administration of anti-PAG monoclonal antibody in combination with anti-PD-1 antibody to mice bearing MC38 tumors limited tumor growth and enhanced T cell infiltration to tumors. Strazza, Mor, and colleagues have developed a specific phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG) antibody that affects the localization of the protein and subsequently T cell function. PAG expression is negatively correlated with cancer survival, and the investigators demonstrate an impact of the antibody on murine tumor growth.
登录
查看更多内容
影响因子：
16.6
作者：
Cartwright, Adam N. R.;Griggs, Jeremy;Davis, Daniel M.
通讯作者：
Davis, Daniel M.
DOI：
10.1016/j.omtm.1020.08.008
发表时间：
2020-12-11
影响因子：
4.7
作者：
Fang，Yuan;Zhang，Yajun;Qian，Qijun
通讯作者：
Qian，Qijun
DOI：
10.1073/pnas.0902621106
发表时间：
2009-08-04
影响因子：
11.1
作者：
Hartman, Nina C.;Nye, Jeffrey A.;Groves, Jay T.
通讯作者：
Groves, Jay T.
影响因子：
--
作者：
Gao, Chao;Xu, Jinsheng;Yu, Qiyao
通讯作者：
Yu, Qiyao
影响因子：
5.3
作者：
Dobenecker, MW;Schmedt, C;Tarakhovsky, A
通讯作者：
Tarakhovsky, A