Alterations of the human gut microbiome in multiple sclerosis.
Alterations of the human gut microbiome in multiple sclerosis.
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DOI：
10.1038/ncomms12015
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发表时间：
2016-06-28
影响因子：
16.6
通讯作者：
Weiner HL
中科院分区：
文献类型：
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作者：
Jangi S;Gandhi R;Cox LM;Li N;von Glehn F;Yan R;Patel B;Mazzola MA;Liu S;Glanz BL;Cook S;Tankou S;Stuart F;Melo K;Nejad P;Smith K;Topçuolu BD;Holden J;Kivisäkk P;Chitnis T;De Jager PL;Quintana FJ;Gerber GK;Bry L;Weiner HL
肠道微生物组在免疫功能中起着重要作用，并与几种自身免疫性疾病有关。在这里，我们使用16 S rRNA测序来研究多发性硬化症（MS，n=60）和健康对照（n=43）受试者的肠道微生物组。MS中的微生物组改变包括甲烷短杆菌和阿克曼氏菌的增加以及丁酸单胞菌的减少，并且与循环T细胞和单核细胞中树突状细胞成熟、干扰素信号传导和NF-κ B信号传导途径中涉及的基因表达的变化相关。与未经治疗的患者相比，接受疾病缓解治疗的患者显示出普雷沃氏菌属和萨特氏菌属丰度增加，八叠球菌属丰度降低。与对照组相比，第二组群的MS患者显示呼吸甲烷升高，这与我们在第一组群中观察到的MS中肠道甲烷短杆菌增加一致。需要进一步的研究来评估观察到的肠道微生物组的变化是否在MS发病机制中发挥作用或作为MS发病机制的结果。 肠道微生物组与几种自身免疫性疾病有关。在这里，作者研究了多发性硬化症患者的肠道微生物组，并发现了某些肠道微生物丰度的改变与免疫防御基因表达变化之间的相关性。
The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n=60) and healthy controls (n=43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of Prevotella and Sutterella, and decreased Sarcina, compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut Methanobrevibacter in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis. The gut microbiome has been implicated in several autoimmune disorders. Here, the authors study the gut microbiome of patients with multiple sclerosis, and find correlations between altered abundance of certain gut microorganisms and changes in expression of immune defence genes.