Minimum estimated incidence in Japan of anaphylaxis to live virus vaccines including gelatin
Minimum estimated incidence in Japan of anaphylaxis to live virus vaccines including gelatin
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DOI：
10.1016/s0264-410x(00)00206-1
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发表时间：
2000-10-15
期刊：
影响因子：
5.5
通讯作者：
Inouye, S
中科院分区：
文献类型：
--
作者：
Sakaguchi, M;Nakayama, T;Inouye, S
我们以前发现，大多数对活病毒疫苗的过敏反应是由疫苗中作为稳定剂的明胶引起的。在我们发表了明胶在过敏反应中的作用的证据之后，日本的疫苗制造商开始从活病毒疫苗中消除明胶。在本研究中，我们试图在明胶消除开始前估计其发生率。从1994年4月至1997年3月，医生和疫苗制造商向国立传染病研究所（NIID）提交了对麻疹、腮腺炎、风疹或水痘疫苗过敏的儿童的血清样本。明胶特异性IgE测定分别在NIID或两个生产商用CAP和ELISA法进行。在3年期间，有44名儿童发生危及生命的严重过敏反应（气道阻塞或过敏性休克），其中41人有抗明胶IgE。有64名儿童有轻度过敏反应（无气道阻塞）; 62名有抗明胶IgE。有100名儿童只有全身皮肤体征，81人有抗明胶IgE。1994-1996年严重过敏反应发生率的估计值分别为：每百万剂含明胶的麻疹、风疹、腮腺炎和水痘疫苗中有6.84、7.31、4.36和10.3例。(C)2000爱思唯尔科技有限公司版权所有。
We have previously found that most occurrences of anaphylaxis to live virus vaccines are caused by gelatin present in the vaccines as a stabilizer. After we published the evidence for the role of gelatin in anaphylaxis, Vaccine manufacturers in Japan began to eliminate gelatin from live virus vaccines. In the present study, we tried to estimate its incidence before the gelatin elimination was started. Physicians and vaccine manufacturers submitted serum samples from children with anaphylaxis to measles, mumps, rubella or varicella vaccine to National Institute of Infectious Diseases (NIID) for 3 years from April 1994 to March 1997. Specific IgE to gelatin was assayed at NIID or two manufacturers by the CAP and ELISA methods. There were 44 children with life-threatening severe anaphylaxis (airway obstruction or anaphylactic shock) during the 3-year period, 41 of whom had anti-gelatin IgE. There were 64 children with mild anaphylaxis (without airway obstruction); 62 had anti-gelatin IgE. There were 100 children with only systemic cutaneous signs; 81 had anti-gelatin IgE. The estimates for the incidence of the severe anaphylaxis in 1994-1996 are: 6.84, 7.31, 4.36, and 10.3 cases per million doses of gelatin-containing measles, rubella, mumps, and varicella vaccines, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.