Metabolic Syndrome and Cognitive Function in Midlife
Metabolic Syndrome and Cognitive Function in Midlife
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DOI：
10.1093/arclin/acaa112
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发表时间：
2021-09-01
影响因子：
2.6
通讯作者：
Haley, Andreana P.
中科院分区：
文献类型：
--
作者：
Foret, Janelle T.;Oleson, Stephanie;Haley, Andreana P.
目的：代谢综合征（MetS）是一组与认知能力下降相关的心血管危险因素。我们调查了中年成年人 MetS 与认知之间的关系。我们假设较高数量的 MetS 成分与执行功能 (EF) 任务的较差表现有关，因为对 EF 至关重要的额叶区域特别容易患心血管疾病。方法：197 名成年人（40-60 岁）参与。使用既定标准评估 MetS。认知领域的综合得分计算如下：整体认知功能（韦克斯勒智力简写量表第二版的子测试）、EF（Stroop 颜色词、数字跨度向后以及轨迹 A 和 B）和记忆力（加州语言学习测试，第二版）。结果：较高数量的 MetS 成分与较弱的 EF-F(4, 191) = 3.94，p = .004，MetS 成分 beta = -.14，p = .044。记忆测试中检测到类似的关系 -F(4, 192) = 7.86, p < .001，MetS 成分 beta = -.15, p = .032。 MetS 的诊断与 EF 域评分不显着相关（beta = -.05，p = .506），但与记忆评分显着相关 -F(4, 189) = 8.81，p < .001，MetS 诊断 beta = -.19，p = .006。 结论：我们的研究结果支持之前将中年 MetS 成分与执行功能障碍联系起来的研究，并证明 MetS 及其成分是 也与记忆功能较差有关。这表明认知脆弱性可以在中年时被发现。中年时期 MetS 的干预可能会改变认知结果。
Objective: Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors associated with cognitive decline. We investigated the relationship between MetS and cognition in middle-aged adults. We hypothesized that higher numbers of MetS components will relate to poorer performance on executive function (EF) tasks as frontal lobe regions critical to EF are particularly vulnerable to cardiovascular disease.Methods: 197 adults (ages 40-60) participated. MetS was evaluated using established criteria. Composite scores for cognitive domains were computed as follows: Global cognitive function (subtests from the Wechsler Abbreviated Scale of Intelligence, 2nd Edition), EF (Stroop Color Word, Digit Span Backward, and Trails A and B), and memory (California Verbal Learning Test, 2 Edition).Results: Higher number of MetS components was related to weaker EF-F(4, 191) = 3.94, p = .004, MetS components beta = -.14, p = .044. A similar relationship was detected for tests of memory-F(4, 192) = 7.86, p < .001, MetS components beta = -.15, p = .032. Diagnosis of MetS was not significantly associated with EF domain score (beta = -.05, p = .506) but was significantly associated with memory scores-F(4, 189) = 8.81, p < .001, MetS diagnosis beta = -.19, p = .006.Conclusions: Our findings support prior research linking MetS components at midlife to executive dysfunction and demonstrate that MetS, and its components are also associated with poorer memory function. This suggests that cognitive vulnerability can be detected at midlife. Interventions for MetS at midlife could alter cognitive outcomes.