Relationship Between Platelet to Lymphocyte Ratio and Stable Coronary Artery Disease: Meta-Analysis of Observational Studies
Relationship Between Platelet to Lymphocyte Ratio and Stable Coronary Artery Disease: Meta-Analysis of Observational Studies
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血小板与淋巴细胞比率与稳定型冠状动脉疾病之间的关系：观察性研究的荟萃分析
DOI：
10.1177/0003319720943810
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发表时间：
2020-07-28
期刊：
影响因子：
2.8
通讯作者：
Cheng, Xiaoshu
中科院分区：
文献类型：
--
作者：
Qiu, Zhiqiang;Jiang, Yu;Cheng, Xiaoshu
最近的研究报道了血小板与淋巴细胞比率（PLR）与急性冠状动脉综合征之间的关系。本研究的目的是探讨PLR与稳定型冠状动脉疾病（CAD）之间的关系。基于电子数据库（Cochrane、PubMed、Elsevier、Medline和Embase）进行系统检索。荟萃分析共纳入14项研究（n = 4,871）。与非CAD组相比，CAD组PLR显著高于非CAD组（P = 0.002）。根据Gensini评分进一步分类，动脉粥样硬化组的PLR高于无动脉粥样硬化组（P < 0.001）。重度动脉粥样硬化组血小板/淋巴细胞比值高于轻度动脉粥样硬化组（P < 0.001）。与冠状动脉侧枝循环不良组相比，冠状动脉侧枝循环良好组PLR明显降低（P < 0.001）。冠状动脉慢流（CSF）患者的PLR明显高于冠状动脉血流正常患者（P = 0.01）。根据目前的证据，PLR升高与稳定的CAD相关，它可能有助于预测CAD严重狭窄、侧支循环和CSF。需要进一步的研究来阐明PLR与稳定CAD之间的关系。
Recent studies have reported a relationship between the platelet to lymphocyte ratio (PLR) and acute coronary syndromes. The aim of the present study was to investigate the association between PLR and stable coronary artery disease (CAD). A systematic search was conducted based on electronic databases (Cochrane, PubMed, Elsevier, Medline, and Embase). A total of 14 studies (n = 4,871) were included in the meta-analysis. Compared with the non-CAD group, PLR was significantly higher in CAD group (P = .002). After further classification according to the Gensini score, the cases with atherosclerosis demonstrated a higher PLR than those without atherosclerosis (P < .001). Platelet to lymphocyte ratio was higher in the severe atherosclerosis group compared with the mild atherosclerosis group (P < .001). Compared with the poor coronary collateral circulation (CCC) group, PLR was significantly lower in the good CCC group (P < .001). The PLR was significantly higher in patients with coronary slow flow (CSF) than those with normal coronary flow (P = .01). On the basis of current evidence, an elevated PLR was associated with stable CAD, and it might be useful for predicting CAD severe stenosis, collateral circulation, and CSF. Future studies are needed to clarify the relationship between PLR and stable CAD.