Reproductive factors, age at maximum height, and risk of three histologic types of breast cancer.
Reproductive factors, age at maximum height, and risk of three histologic types of breast cancer.
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DOI：
10.1158/1055-9965.epi-08-0641
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Li CI
中科院分区：
文献类型：
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作者：
Beaber EF;Holt VL;Malone KE;Porter PL;Daling JR;Li CI
许多研究已经评估了成熟和生殖相关因素与乳腺癌风险之间的关系，但很少有研究评估这些因素与绝经后妇女不同组织学类型的乳腺癌之间的关系。在2000-2004年华盛顿州西雅图-普吉特海湾地区55-74岁女性的人群病例对照研究中，我们采用多元逻辑回归评估了最大身高年龄和生殖因素对浸润性乳腺癌风险的影响，这些患者分为三组（524例导管组，324例小叶组，196例导管-小叶组）和469例对照。83%的病例通过集中组织检查确定组织学类型。初潮年龄和最高身高年龄与导管小叶癌的风险呈负相关（两种暴露的趋势p值均为0.04），但导管或小叶癌的风险不相关。与未生育妇女相比，已生育妇女患所有组织学类型乳腺癌的风险降低了50%。我们观察到，与≤19岁相比，≥30岁首次活产的组织学类型的风险增加相似。与从未母乳喂养的分娩妇女相比，母乳喂养的妇女患导管癌的风险降低（优势比=0.7,95%可信区间：0.5-0.9），但小叶癌或导管小叶癌的风险降低。为了了解导管癌、小叶癌和导管小叶癌的病因差异，值得通过组织学进一步探索乳腺癌的风险。
Numerous studies have evaluated the association between factors related to maturation and reproduction and breast cancer risk, but few have assessed how these factors are related to different histologic types of breast cancer among postmenopausal women. We used polytomous logistic regression to assess the effect of age at maximum height and reproductive factors on risk of invasive breast cancer by histologic type in three case groups (524 ductal, 324 lobular, 196 ductal-lobular) and 469 controls enrolled in a population-based case-control study of women aged 55–74 years residing in the Seattle-Puget Sound region of Washington State (2000–2004). Histologic type was determined by a centralized tissue review for 83% of cases. Age at menarche and age at maximum height were inversely associated with risk of ductal-lobular carcinoma (p-value for trend=0.04 for both exposures), but not ductal or lobular carcinoma. Relative to nulliparous women, parous women had a 50% reduced risk of all histologic types of breast cancer. We observed similar increases in risk across histologic types associated with having a first live birth at ≥30 years of age compared to ≤19 years of age. Compared to parous women who never breastfed, those who breastfed had a reduced risk of ductal carcinoma (odds ratio=0.7, 95% confidence interval: 0.5–0.9), but not lobular or ductal-lobular carcinoma. Further exploration of breast cancer risk by histology is merited in order to understand differences in the etiology of ductal, lobular, and ductal-lobular carcinoma.