Carotid intraplaque hemorrhage predicts recurrent symptoms in patients with high-grade carotid stenosis
Carotid intraplaque hemorrhage predicts recurrent symptoms in patients with high-grade carotid stenosis
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DOI：
10.1161/strokeaha.106.473066
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发表时间：
2007-05-01
期刊：
影响因子：
8.3
通讯作者：
Auer, Dorothee P.
中科院分区：
文献类型：
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作者：
Altaf, Nishath;MacSweeney, Shane T.;Auer, Dorothee P.
背景和目的-颈动脉斑块内出血（IPH），已知与斑块不稳定性有关，可能具有更高的卒中风险。本研究的目的是评估通过MRI识别IPH是否可预测复发性临床脑血管事件。方法-66例高度症状性颈动脉狭窄患者接受颈动脉MRI检查，并随访至颈动脉内膜切除术或30 d.Results -66例患者中位随访时间为33.5 d，44例（66.7%）经MRI发现有同侧颈动脉IPH。15例复发事件与同侧颈动脉IPH相关。在没有IPH的情况下，仅发生了2起复发事件。IPH增加了复发性缺血的风险（风险比=4.8; 95%CI =1.1 - 20.9，P
Background and Purpose - Carotid intraplaque hemorrhage ( IPH), known to be associated with plaque instability, may convey a higher stroke risk. The aim of this study was to assess whether the identification of IPH by MRI predicts recurrent clinical cerebrovascular events.Methods - Sixty-six patients with high-grade symptomatic carotid stenosis underwent MRI of the carotid arteries and were followed until carotid endarterectomy or 30 days.Results - Of the 66 patients with a median follow up of 33.5 days, 44 ( 66.7%) were found on MRI to have ipsilateral carotid IPH. Fifteen recurrent events were associated with ipsilateral carotid IPH. Only 2 recurrent events occurred in the absence of IPH. IPH increased the risk of recurrent ischemia ( hazard ratio=4.8; 95% CI=1.1 to 20.9, P