Is there a relationship between adult neurogenesis and neuron generation following injury across evolution?
Is there a relationship between adult neurogenesis and neuron generation following injury across evolution?
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DOI：
10.1111/j.1460-9568.2011.07833.x
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发表时间：
2011-09-01
影响因子：
3.4
通讯作者：
Ferretti, Patrizia
中科院分区：
文献类型：
--
作者：
Ferretti, Patrizia
所有脊椎动物在出生后都可以在神经系统的不同区域产生新的神经元，但只有一些低等脊椎动物（鱼类和两栖动物）可以显著修复一些神经结构，包括脑、脊髓、视网膜、嗅觉和听觉前庭系统，以补偿神经组织的损失并恢复重要的功能。然而，在爬行动物和鸟类，甚至哺乳动物中也发现了一些再生能力。神经发生确实发生在所有成年脊椎动物的中枢神经系统中，这一认识挑战了成人中枢神经系统中神经发生区域的维持与再生能力之间存在简单关系的观点。这篇综述的目的是根据最近的文献回顾神经发生和再生的关系，并讨论可能有助于阐明成人神经发生和再生之间关系的框架。这可能为利用人类中枢神经系统的再生提供有用的范例。
All vertebrates can produce new neurons postnatally in discrete regions of their nervous system, but only some lower vertebrates (fish and amphibians) can significantly repair several neural structures, including brain, spinal cord, retina, olfactory and auditory-vestibular system, to compensate for neural tissue loss and recover significant functionality. Some regenerative ability, however, is found also in reptiles and birds, and even in mammals. The recognition that neurogenesis indeed occurs in the CNS of all adult vertebrates challenges the view that there is a simple relationship between maintenance of neurogenic regions in the adult CNS and regenerative capability. The aim of this review is to revisit this relationship in the light of recent literature focusing on selected examples of neurogenesis and regeneration, and discuss possible frameworks that may help to elucidate the relationship between adult neurogenesis and regeneration. This could provide useful paradigms for harnessing regeneration in the human CNS.