Astrin: A Key Player in Mitosis and Cancer
Astrin: A Key Player in Mitosis and Cancer
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DOI：
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发表时间：
2020
影响因子：
5.5
通讯作者：
Ou Sha
中科院分区：
文献类型：
--
作者：
Zhenguang Ying;Jing Yang;Wei Li;Xia Wang;Zeyao Zhu;Weipeng Jiang;Chunman Li;Ou Sha
Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule and integrity of centrosomes and promoting the centriole duplication. In addition, Astrin was quite recently found to be abnormally highly expressed in a variety of cancers. Astrin promotes the development of cancer by participating in various molecular pathways and is considered as a potential prognostic and survival predictor.
