The cellular biology of erythropoietin receptors
The cellular biology of erythropoietin receptors
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DOI：
10.1634/theoncologist.8-suppl_1-15
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发表时间：
2003-01-01
期刊：
影响因子：
5.8
通讯作者：
Lappin, T
中科院分区：
文献类型：
--
作者：
Lappin, T
长期以来，人们一直认为促红细胞生成素只作为一种激素发挥作用，而红细胞生成素是红细胞产生的主要调节剂，现在人们知道它具有完整的活性范围。大脑、卵巢、输卵管、子宫和睾丸等器官都有促红细胞生成素受体。由于促红细胞生成素受体存在于旁分泌和自分泌系统，以及激素系统中，使用人促红细胞生成素的有益作用可能超出其提高红细胞压积的作用。未来甚至有可能在不损害周围组织的情况下，利用受体将药物靶向肿瘤。
Long thought to act only as a hormone that was the primary regulator of red blood cell production, erythropoietin, is now known to have a whole spectrum of activity. Organs such as the brain, ovary, oviduct, uterus, and testis have erythropoietin receptors. Because erythropoietin receptors exist in the paracrine and autocrine systems, as well as the hormonal system, the beneficial effects of administering human erythropoietin are likely to extend beyond its effect in raising hematocrit. It may even be possible in the future to use the receptors to target a drug to a tumor without damaging the surrounding tissue.