Automatic quantitation of localized in vivo 1H spectra with LCModel
Automatic quantitation of localized in vivo 1H spectra with LCModel
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DOI：
10.1002/nbm.698
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发表时间：
2001-06-01
影响因子：
2.9
通讯作者：
Provencher, SW
中科院分区：
文献类型：
--
作者：
Provencher, SW
LCModel 方法将体内光谱分析为来自各个代谢物溶液的模型体外光谱的线性组合。使用完整的模型光谱，而不是单独的共振，以便将最大的先验信息纳入分析中。几乎无模型的约束正则化方法自动解释体内的基线和线形，而不对其施加限制性参数化形式。 LCModel 是自动的（非交互式），无需主观输入。获得代谢物浓度及其不确定性（Cramer-Rao 下限）的近似最大似然估计。此处使用 LCModel 对来自 1.5 至 9.4 T 场和各种序列（特别是短 TE）的用户的光谱进行分析，以说明 LCModel 和质子 MRS 的功能和局限性。版权所有 (C) 2001 John Wiley & Sons, Ltd.
The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model in vitro spectra from individual metabolite solutions. Complete model spectra, rather than individual resonances, are used in order to incorporate maximum prior information into the analysis. A nearly model-free constrained regularization method automatically accounts for the baseline and lineshape in vivo without imposing a restrictive parameterized form on them. LCModel is automatic (non-interactive) with no subjective input. Approximately maximum-likelihood estimates of the metabolite concentrations and their uncertainties (Cramer-Rao lower bounds) are obtained. LCModel analyses of spectra from users with fields from 1.5 to 9.4 T and a wide range of sequences, particularly with short TE, are used here to illustrate the capabilities and limitations of LCModel and proton MRS. Copyright (C) 2001 John Wiley & Sons, Ltd.