Effect of geometry on drug release from 3D printed tablets
Effect of geometry on drug release from 3D printed tablets
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DOI：
10.1016/j.ijpharm.2015.04.069
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发表时间：
2015-10-30
影响因子：
5.8
通讯作者：
Gaisford, Simon
中科院分区：
文献类型：
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作者：
Goyanes, Alvaro;Martinez, Pamela Robles;Gaisford, Simon
这项工作的目的是探索将热熔融挤压(HME)和3D打印(3DP)技术相结合的可行性，以期生产出用传统方法难以生产的不同形状的片剂。纤维挤出机被用来获得大约。4%扑热息痛负载的聚乙烯醇长丝具有适合于熔融沉积建模3DP的特性。成功地实现了五种不同的平板电脑几何形状的3D打印-立方体、棱锥体、圆柱体、球体和环面。印刷工艺不影响药物的稳定性。片剂的药物释放不依赖于比表面积，而依赖于比表面积与体积之比，表明几何形状对药物释放的影响。侵蚀介导的过程控制了药物的释放。这项工作展示了3DP制造不同几何形状的片剂的潜力，其中许多形状的片剂通过粉末压制制造将是具有挑战性的。(C)2015爱思唯尔B.V.保留所有权利。
The aim of this work was to explore the feasibility of combining hot melt extrusion (HME) with 3D printing (3DP) technology, with a view to producing different shaped tablets which would be otherwise difficult to produce using traditional methods. A filament extruder was used to obtain approx. 4% paracetamol loaded filaments of polyvinyl alcohol with characteristics suitable for use in fused-deposition modelling 3DP. Five different tablet geometries were successfully 3D-printed-cube, pyramid, cylinder, sphere and torus. The printing process did not affect the stability of the drug. Drug release from the tablets was not dependent on the surface area but instead on surface area to volume ratio, indicating the influence that geometrical shape has on drug release. An erosion-mediated process controlled drug release. This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction. (C) 2015 Elsevier B.V. All rights reserved.