Voyage au bout de la nuit: Aβ and tau imaging in dementias.
Voyage au bout de la nuit: Aβ and tau imaging in dementias.
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Voyage au bout de la night：痴呆症中的 Aβ 和 tau 蛋白成像。
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
V. Villemagne
中科院分区：
文献类型：
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作者：
M. D. Zwan;N. Okamura;M. Fodero;S. Furumoto;C. Masters;C. C. Rowe;V. Villemagne
在过去的十年中，已经见证了示踪剂的发展和表征，用于体内神经病理学的评价。这些示踪剂，即β-淀粉样蛋白（Aβ）和后来的tau蛋白的引入，提供了改变景观和完善我们对大脑中Aβ和tau蛋白沉积的理解的工具，允许调查原因，完善诊断和改善主要神经退行性疾病的治疗，如阿尔茨海默病（AD），慢性创伤性脑病（CTE）和额颞叶变性（FTLD）。Aβ和tau成像允许检查这些疾病标志物随时间的局部和整体变化以及它们与其他相关参数（如认知表现和神经退行性变化）的关系。Aβ和tau成像将能够确定Aβ和tau在衰老和疾病中的作用-以及相互作用。Aβ和tau成像价值不仅在于作为诊断、预后或进展标志物，而且还在于作为疾病的替代标志物，对于患者招募和疾病特异性治疗的疗效评价至关重要。
The last decade has witnessed the development and characterization of tracers for the evaluation of neuropathology in vivo. The introduction of these tracers, namely β-amyloid (Aβ) and later tau, are providing the tools to change the landscape and refine our understanding of Aβ and tau deposition in the brain, allowing to investigate the causes, refine diagnosis and improve treatment of major neurodegenerative conditions such as Alzheimer's disease (AD), chronic traumatic encephalopathy (CTE) and frontotemporal lobar degeneration (FTLD). Aβ and tau imaging allow examination of the regional and global changes of these disease markers over time as well as their relationship with other relevant parameters such as cognitive performance and neurodegenerative changes. Aβ and tau imaging will enable to establish the role Aβ and tau play -and interplay- in aging and disease. Aβ and tau imaging value resides in being not only diagnostic, prognostic or progression markers, but also surrogate markers of disease, crucial for patient recruitment and efficacy evaluation of disease-specific therapies.