From genes to circuits and behaviors: Neuropeptides expand the coding potential of the nervous system.
From genes to circuits and behaviors: Neuropeptides expand the coding potential of the nervous system.
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DOI：
10.4161/worm.27730
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Chalasani SH
中科院分区：
文献类型：
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作者：
Leinwand SG;Chalasani SH
神经肽信号传导重塑化学感应电路的组成并塑造秀丽隐杆线虫中的行为。我们报告说，ASE左（ASEL）盐感官神经元使用普洛蛋白转化酶Bli-4来裂解胰岛素样肽INS-6。 INS-6肽是从ASEL神经元中释放出的，响应于盐刺激的大变化，但不会释放出很小的变化。快速INS-6信号在功能上将AWC嗅觉的感觉神经元转化为神经回路中的中间神经元的高盐。这种新电路配置增强了对高盐的行为吸引力。在这里，在基因，电路和行为的背景下，我们讨论了神经肽处理和信号传导的不同模式，这些模式扩大了神经系统的编码潜力。首先，神经肽加工和释放基因准备胰岛素肽在神经系统中发出信号。其次，这种神经肽信号传导使神经回路的通信多样化，并引入了电路级的灵活性。最后，由此产生的多感觉神经元和电路可以驱动精心调整的行为选择。
Neuropeptide signaling remodels the composition of a chemosensory circuit and shapes behavior in Caenorhabditis elegans. We reported that the ASE left (ASEL) salt sensory neuron uses a proprotein convertase, BLI-4, to cleave the insulin-like peptide INS-6. INS-6 peptides are released from the ASEL neuron in response to large, but not small changes in salt stimuli. Fast INS-6 signaling functionally transforms the AWC olfactory sensory neuron into an interneuron in the neural circuit for high salt. This new circuit configuration potentiates behavioral attraction to high salt. Here, in the context of genes, circuits, and behaviors, we discuss the diverse modes of neuropeptide processing and signaling, which expand the coding potential of the nervous system. First, neuropeptide processing and release genes prepare insulin peptides to signal in the nervous system. Second, this neuropeptide signaling diversifies the communication of neural circuits and introduces circuit-level flexibility. Finally, the resulting multisensory neurons and circuits drive finely tuned behavioral choices.