Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps
Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps
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DOI：
10.1126/science.1111387
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发表时间：
2005-07-22
期刊：
影响因子：
56.9
通讯作者：
Lewin, HA
中科院分区：
文献类型：
--
作者：
Murphy, WJ;Larkin, DM;Lewin, HA
为了解决哺乳动物染色体进化的基本问题，比较了来自5个哺乳动物目的8个遗传学上不同的物种的基因组组织。哺乳动物目内的染色体进化速率被发现增加，因为第三纪的边界。在哺乳动物进化过程中，近20%的染色体断裂点区域被重复使用;这些重复使用的位点也富含着丝粒。对进化断点区域内和周围的基因含量的分析显示，相对于全基因组平均值，基因密度增加。我们发现，部分重复填充的灵长类动物特有的断点，往往侧翼倒染色体片段，暗示它们在染色体重排的作用。
The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.